公开(公告)号：US20240060098A1

公开(公告)日：2024-02-22

申请号：US18267483

申请日：2021-12-17

Applicant: BASF SE

Inventor： Nicholas A. LYONS ,  Rui ZHOU ,  David NUNN

IPC: C12P7/24 ,  C12N9/02 ,  C12N9/06

CPC classification number: C12P7/24 ,  C12N9/0008 ,  C12N9/0016 ,  C12Y102/01067 ,  C12Y104/01013

Abstract: The present invention discloses mutant strains of Amycolatopsis sp. ATCC 39116 suitable for the production of natural vanillin using ferulic acid as a feedstock. More specifically, the present invention discloses mutant strains having mutations that reduce the degradation of vanillin to vanillic acid.

公开(公告)号：US20240060097A1

公开(公告)日：2024-02-22

申请号：US18267478

申请日：2021-12-17

Applicant: BASF SE

Inventor： Nicholas A. LYONS ,  Rui ZHOU ,  David NUNN

IPC: C12P7/22 ,  C12N1/20 ,  C07K14/195 ,  C12N15/01

CPC classification number: C12P7/22 ,  C12N1/20 ,  C07K14/195 ,  C12N15/01

Abstract: A chemical mutagenic approach and a screening protocol were followed to select mutant strains of Amycolatopsis sp. with the ability to produce natural vanillin at high yields without any lag period. The resulting mutant strains are free of any exogeneous genetic elements and can be qualified as non-genetically modified organisms (non-GMOs) for regulatory purposes.