公开(公告)号：US3823236A

公开(公告)日：1974-07-09

申请号：US24644272

申请日：1972-04-21

Applicant: BAYER AG

Inventor： BUECHEL K ,  GREWE F ,  SCHEINPFLUG H

IPC: A01N37/40 ,  A01N9/20 ,  A01N9/24

CPC classification number: A01N37/40

Abstract: FUNGICIDAL AND BACTERICIDAL COMPOSITIONS CONTAINING, AND METHODS OF COMBATING FUNGI AND BACTERIA USING, A 2-ACYLOXBENZOIC ACID ANILIDE OF THE GENERAL FORMULA

1-(((R2)N-PHENYL)-NH-CO-),2-(R1-CO-O-),3-Y,5-X-BENZENE

IN WHICH R1 IS ALKYL OR ALKOXY OF 1 TO 6 CARBON ATOMS, X AND Y EACH INDEPENDENTLY IS CHLORINE, BROMINE IOR TERTIARY BUTYL, OR X IS HYDROGEN PROVIDED THAT Y IS NITRO, OR Y IS HYDROGEN PROVIDED THAT X IS CHLORINE AND R1 IS ALKOXY OR 1 TO 4 CARBON ATOMS, N IS 1,2,3, OR 4, AND R2 IS LOWER ALKYL, HALO-LOWER ALKYL, HALOGEN, NITRO, LOWER ALKOXYCARBONYLOXY, LOWER ALKOXY OR LOWER ALKYLMERCAPTO.

公开(公告)号：US3709901A

公开(公告)日：1973-01-09

申请号：US3709901D

申请日：1970-03-04

Applicant: BAYER AG

Inventor： DRABER W ,  PLEMPEL M ,  REGEL E ,  BUECHEL K

IPC: C07D233/54 ,  C07D233/56 ,  C07D233/64 ,  C07D521/00 ,  C07D99/02

CPC classification number: C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: SUBSTITUTED N-BENZYLIMIDAZOLES OF THE FORMULA:

2-R1,3-(((X)M-PHENYL)-C(-A)(-B)-),4-R2,5-R3-IMIDAZOLE

WHEREIN R1, R2 AND R3 ARE AEACH HYDROGEN, STRAIGHT OR BRANCHED CHAIN LOWER ALKYL OR STRAIGHT OR BRANCHED CHAIN LOWER AKENYL, X IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY, LOWER ALKYLMERCAPTO, LOWER ALKENYLMERCAPTO, TRIFLUOROMETHYL, HALOGEN, NITRO, CYANO, AMINO OR AMINO SUBSTITUTED BY 1 OR 2 ALIPHATIC MOIETIES, M IS 1 OR 2, A IS PHENYL, SUBSTITUTED PHENYL, PYRIDYL, LOWER ALKYL OR CYCLOAKYL, B IS A 5-MEMBERED HETEROAROMATIC RING OF THE FORMULA:

Y-(DN
WHEREIN D IS CH OR N, E IS OXYGEN, SULPHUR, N-LOWER ALKYL OR N-ARYL, Y IS HYDROGEN, 1 OR 2 LOWER ALKYLS, 1 OR 2 HALOGENS, ARYL OR SUBSTITUTED ARYL, AND N IS 1 OR 2, ARE PRODUCED BY REACTING A COMPOUND OF THE FORMULA:

((X)M-PHENYL)-C(-A)(-B)-Z

WHEREIN A, B, X AND M ARE AS ABOVE DEFINED AND Z IS CHLORINE OR BROMINE, WITH AT LEAST THE THEORETICALLY NECESSARY AMOUNT OF IMIDAZOLE, OPTIONALLY IN THE PRESENCE OF AN ACID ACCEPTOR, IN A POLAR ORGANIC SOLVENT, AT A TEMPERATURE OF FROM 20* C. TO 150* C. THESE SUBSTITUTED N-BENZYLIMIDAZOLES ARE USEFUL AS ANTIMYCOTICS AND ARE EFFECTIVE AGAINST BOTH YEASTS AND DERMATOPHYTES. THESE COMPOUNDS ARE EFFECTIVE AGAINST A WIDE RANGE OF FUNGI PATHOGENIC TO HUMANS AND ANIMALS.

公开(公告)号：US3842078A

公开(公告)日：1974-10-15

申请号：US28357672

申请日：1972-08-24

Applicant: BAYER AG

Inventor： PLEMPEL M ,  METZGER C ,  BUECHEL K ,  MEISER W

IPC: C07C205/56 ,  C07D233/60 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D87/38

CPC classification number: C07D401/06 ,  C07C205/56 ,  C07D403/06 ,  C07D413/06

Abstract: 1. DIPHENYL-IMIDAZOLYL-ACETIC ACID MORPHOLIDE OR THE HYDROCHLORIDE SALT THEREOF.

公开(公告)号：US3787415A

公开(公告)日：1974-01-22

申请号：US3787415D

申请日：1971-03-02

Applicant: BAYER AG

Inventor： DRABER W ,  PLEMPEL M ,  BUECHEL K ,  REGEL E

IPC: C07D403/10 ,  A61K31/495 ,  A61K31/505 ,  C07D241/12 ,  C07D403/06 ,  C07D521/00 ,  C07D51/76

CPC classification number: C07D231/12 ,  A61K31/495 ,  A61K31/505 ,  C07D233/56 ,  C07D241/12 ,  C07D249/08 ,  C07D403/06

Abstract: N-METHYL-IMIDAZOLE DERIVATIVES OF THE FORMULA

1-(Y-C(-X)(-Z)-)IMIDAZOLE

OR A PHARAMECUTICALLY ACCEPTABLE NON-TOXIC SALT THEREOF, WHEREIN X IS AN UNSUBSTITUTED OR SUBSTITUTED 6-MEMBERED HETEROAROMATIC MOIETY HAVING TWO NITRO HETEROATOMS, Y IS AN UNSUBSTITUTED OR SUBSTITUTED ALIPHATIC MOIETY, AN UNSUBSTITUTED OR SUBSTITUTED CYCLOALIPHATIC MOIETY, AN UNSUBSTITUTED OR SUBSTITUTED ARALKYL MOIETY OR AN UNSUBSTITUTED OR SUBSTITUTED ARYL MOIETY, AND Z IS AN UNSUBSTITUTED OR SUBSTITUTED ALIPHATIC MOIETY, AN UNSUBSTITUTED OR SUBSTITUTED CYCLOALIPHATIC MOIETY, AN UNSUBSTITUTED OR SUBSTITUTED ARALKYL MOIETY, AN UNSUBSTITUTED OR SUBSTITUTED ARYL MOIETY, AN UNSUBSTITUTED OR SUBSTITUTED PYRIDYL MOIETY OR AN ALKOXYCARBONYL MOIETY ARE USEFUL AS ANTIMYCOTIC AGENTS.

公开(公告)号：US3794653A

公开(公告)日：1974-02-26

申请号：US3794653D

申请日：1972-01-05

Applicant: BAYER AG

Inventor： DRABER W ,  REGEL E ,  BUECHEL K ,  PLEMPEL M

IPC: C07D233/54 ,  C07D233/56 ,  C07D233/64 ,  C07D521/00 ,  C07D31/46 ,  C07D31/50

CPC classification number: C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: SUBSTITUTED N-BENZYLIMIDAZOLES OF THE FORMULA:

1-(((X)M-PHENYL)-C(-A)(-B)-),2-R1,4-R3,5-R4-IMIDAZOLE

WHEREIN R1, R2 AND R3 ARE EACH HYDROGEN, STRAIGHT OR BRANCHED CHAIN LOWER ALKYL OR STRAIGHT OR BRANCHED CHAIN LOWER ALKENYL, X IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY, LOWER ALKYLMERCAPTO,LOWER ALKENYLMERCAPTO, TRIFLUOROMETHYL,HALOGEN,NITRO, CYANO, AMINO OR AMINO SUBSTITUTED BY 1 OR 2 ALIPHAIC MOIETIES. M IS 1 OR 2 A IS PHENYL; SUBSTITUTED PHENYL, PYRIDYL,LOWER ALKYL OR CYCLOALKYL, B US A 5-MEMBERED HETEROAROMATIC RING OF THE FORMULA

E
WHEREIN D IS CH OR N E IS OXYGEN, SULPHUR,N-LOWER ALKYL OR N-ARYL, Y IS HYDROGEN, 1 OR 2 LOWER ALKYLS,1 OR 2 HALOGENS, ARYL OR SUBSTITUTED ARYL, AND N IS 1 OR 2, ARE PRODUCED BY REACTING A COMPOUND OF THE FORMULA:

(X)M,(A-C(-B)(-Z)-)BENZENE

WHEREIN A, B, X AND M ARE AS ABOVE DEFINED AND Z IS CHLORINE OR BROMINE,WITH AT LEAST THE THEORETICALLY NECESSARY AMOUNT OF IMIDAZOLE, OPTIONALLY IN THE PRESENCE OF AN ACID ACCEPTOR,IN A POLAR ORGANIC SOLVENT, AT A TEMPERATURE OF FROM 20* C. TO 150*C. THESE SUNSTITUTED N-BENZYLIMID AZOLES ARE USEFUL AS ANTIMYCOTICS AND ARE EFFECTIVE AGAINST BOTH YEASTS AND DERMATOPHYTES. THESE COMPOUNDS ARE EFFECTIVE AGAINST A WIDE RANGE OF FUNGI PATHOGENIC TO HUMANS AND ANIMALS.

公开(公告)号：US3786131A

公开(公告)日：1974-01-15

申请号：US13254271

申请日：1971-04-08

Applicant: BAYER AG

Inventor： HAMMANN I ,  UNTERSTENHOEFER G ,  BUECHEL K ,  DRABER W

IPC: A01N37/52 ,  A01N9/12 ,  A01N9/20

Abstract: A-(HALO, CYANO, NITRO AND AZIDO)-A-(ALKANOYL, CARBOALKOXY (I.E. ALKOXY CARBONYL), AMINO AND MONO- AND DIALKYLAMINO)-CARBONYL-(UNSUBSTITUTED AND MOMO TO PENTA ALKYL AND/OR ELECTRONEGATIVE SUBSTITUENT (E.G. HALO, NITRO, CYANO, TRIFLUOROMETHYL, TRIFLUOROMETHYL-MERCAPTO, SULFONYL, AND -SULFOXYL, ALKOXY, ALKYL SULFONYL AND/OR DIMETHYLAMINO SULFONYL)-SUBSTITUTED) PHENYL HYDRAZONES AND THEIR CORRESPONDING ALKALI METAL, ALKALINE EARTH METAL AND AMINE SALTS, WHICH POSSES PERTICIDAL, ESPECIALLY ACARICIDAL AND INSECTICIDAL, PROPERTIES AND WHICH MAY BE PRODUCED BY CONVENTIONAL METHODS.

公开(公告)号：US3769422A

公开(公告)日：1973-10-30

申请号：US3769422D

申请日：1971-02-17

Applicant: BAYER AG

Inventor： TIMMLER H ,  DRABER W ,  KASPERS H ,  SCHEINPFLUG H ,  BUECHEL K ,  GREWE F

IPC: C07D233/56 ,  C07D521/00 ,  A01N9/22

CPC classification number: C07D233/56 ,  C07D231/12 ,  C07D249/08

Abstract: FUNGICIDAL COMPOSITIONS OF AND METHODS OF COMBATING FUNGI USING CERTAIN N - ARYLALKYLIMIDAZOLES OF THE FORMULA

1-((X)N-C6H4-C(-A)(-R)-),2-R''",4-R",5-R''-IMIDAZOLE

IN WHICH R IS AN ALIPHATIC OR CYCLOALIPHATIC RADICAL WITH UP TO 20 CARBON ATOMS, R'', R" AND R"'', WHICH MAY BE THE SAME OR DIFFERENT, ARE HYDROGEN, OR ALKYL, ALKENYL OR CYCLOALKYL WITH UP TO 6 CARBON ATOMS,, A IS AN OPTIONALLY SUBSTITUTED ARYL, PYRIDYL, ALIPHATIC OR CYCLOALIPHATIC RADICAL WITH UP TO 12 CARBON ATOMS, X IS AN ALKYL, ALKOXY OR ALKYLMERCAPTO RADICAL WITH UP TO 6 CARBON ATOMS, OR AN ARYLOXY OR PHENYL RADICAL, OR AN ELECTRONEGATIVE RADICAL OR A BASIC RADICAL, AND N IS 0, 1 OR 2, AS WELL AS SALTS OF THESE COMPOUNDS.