公开(公告)号：US3801590A

公开(公告)日：1974-04-02

申请号：US3801590D

申请日：1970-12-09

Applicant: BAYER AG

Inventor： DRABER W ,  EUE L ,  SCHMIDT R ,  REGEL E ,  BUCHEL K

IPC: C07D249/08 ,  C07D261/08 ,  C07D521/00 ,  C07D85/22

CPC classification number: C07D233/56 ,  C07D231/12 ,  C07D249/08 ,  C07D261/08

Abstract: N-BENZYLTRIAZOLES OF THE FORMULA

(TRIAZOLYL-C(-A)(-B)-),(X)M-BENZENE

IN WHICH TRIAZOYLY IS 1,2,4 OR 1,2,3 TRIAZOLYL WHICH MAY BE SUBSTITUTED; X IS HALOGN, TRIFLUOROMETHYL, LOWER ALKYL, LOWER ALKOXY, LOWER ALKLTHIO, ARYL, NITRO, CYCANO OR (ALKYLATED) AMINO; M IS 0, 1 OR 2; A IS OPTIONALLY SUBSTITUTED PHENYL, PYRIDYL, ALKYL OR CYCLOALKYL; AND B IS A 5-MEMBERED HETEROCYCLIC RING, E.G., N-HETEROCYCLE; AND HEIR SALT ARE OUTSTANDINGLY EFFECTIVE IN REGULATING PLANT GROWTH, E.G., INHIBITING, STIMULATING OR ALTERING PLANT GROWTH.

Abstract translation: 新型的N-苄基三唑，其中三唑啉是可以被取代的1,2,4或1,2,3三唑; X为卤素，三氟甲基，低级烷基，低级烷氧基，低级烷硫基，芳基，硝基，氰基或（烷基化）氨基; M IS 0，1或2; A是任选取代的苯基，吡啶基，烷基或环烷基; 并且B是5元杂环，例如N-杂环; 并且它们的销售在调节植物生长，E.G.，抑制，刺激或改变植物生长方面是非常有效的。

公开(公告)号：US3711498A

公开(公告)日：1973-01-16

申请号：US3711498D

申请日：1972-01-17

Applicant: BAYER AG

Inventor： BUCHEL K ,  REGEL E ,  PLEMPEL M

IPC: C07D233/62 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D521/00 ,  C07D49/36

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18

Abstract: N-TRITYL-IMIDAZOLES AND SALTS THEREOF OF THE FORMULA*

1-(((X)N-PHENYL)((X'')N-PHENYL)((X")N-PHENYL)-C-),2-R,4-R1,

5-R2-IMIDAZOLE

WHEREIN R, R1 AND R2 ARE HYDROGEN, LOWER ALKYL OR PHENYL, OR R1 AND R2 TOGETHER FORM AN ANELLATED BENZENE RING, X,X'' AND X" ARE ALKYL OF 1 TO 12 CARBON ATOMS OR AN ELECTRO-NEGATIVE MOIETY, AND N, N'' AND N" ARE AN INTEGER FROM 0 TO 2, OR PHARMACEUTICALLY ACCEPTABLE ACID SALTS THEREOF MAY BE PRODUCED BY REACTING A SILVER SALT OR ALKALI METAL SALT OF AN IMIDAZOLE OF THE FORMULA:

2-R,4-R1,5-R2-IMIDAZOLE

WITH A TRITYL HALIDE OF THE FORMULA:

(((X)N-PHENYL-),((X'')N-PHENYL-)((X")N"-PHENYL-)C-HAL

WHEREIN THE SUBSTITUENTS ARE AS ABOVE DEFINED AND HAL IS HALOGEN. THESE COMPOUNDS ARE USEFUL AS ANTIMYCOTICS.

公开(公告)号：US3709901A

公开(公告)日：1973-01-09

申请号：US3709901D

申请日：1970-03-04

Applicant: BAYER AG

Inventor： DRABER W ,  PLEMPEL M ,  REGEL E ,  BUECHEL K

IPC: C07D233/54 ,  C07D233/56 ,  C07D233/64 ,  C07D521/00 ,  C07D99/02

CPC classification number: C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: SUBSTITUTED N-BENZYLIMIDAZOLES OF THE FORMULA:

2-R1,3-(((X)M-PHENYL)-C(-A)(-B)-),4-R2,5-R3-IMIDAZOLE

WHEREIN R1, R2 AND R3 ARE AEACH HYDROGEN, STRAIGHT OR BRANCHED CHAIN LOWER ALKYL OR STRAIGHT OR BRANCHED CHAIN LOWER AKENYL, X IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY, LOWER ALKYLMERCAPTO, LOWER ALKENYLMERCAPTO, TRIFLUOROMETHYL, HALOGEN, NITRO, CYANO, AMINO OR AMINO SUBSTITUTED BY 1 OR 2 ALIPHATIC MOIETIES, M IS 1 OR 2, A IS PHENYL, SUBSTITUTED PHENYL, PYRIDYL, LOWER ALKYL OR CYCLOAKYL, B IS A 5-MEMBERED HETEROAROMATIC RING OF THE FORMULA:

Y-(DN
WHEREIN D IS CH OR N, E IS OXYGEN, SULPHUR, N-LOWER ALKYL OR N-ARYL, Y IS HYDROGEN, 1 OR 2 LOWER ALKYLS, 1 OR 2 HALOGENS, ARYL OR SUBSTITUTED ARYL, AND N IS 1 OR 2, ARE PRODUCED BY REACTING A COMPOUND OF THE FORMULA:

((X)M-PHENYL)-C(-A)(-B)-Z

WHEREIN A, B, X AND M ARE AS ABOVE DEFINED AND Z IS CHLORINE OR BROMINE, WITH AT LEAST THE THEORETICALLY NECESSARY AMOUNT OF IMIDAZOLE, OPTIONALLY IN THE PRESENCE OF AN ACID ACCEPTOR, IN A POLAR ORGANIC SOLVENT, AT A TEMPERATURE OF FROM 20* C. TO 150* C. THESE SUBSTITUTED N-BENZYLIMIDAZOLES ARE USEFUL AS ANTIMYCOTICS AND ARE EFFECTIVE AGAINST BOTH YEASTS AND DERMATOPHYTES. THESE COMPOUNDS ARE EFFECTIVE AGAINST A WIDE RANGE OF FUNGI PATHOGENIC TO HUMANS AND ANIMALS.

公开(公告)号：US3836663A

公开(公告)日：1974-09-17

申请号：US37281373

申请日：1973-06-22

Applicant: BAYER AG

Inventor： REGEL E ,  BUCHEL K ,  PLEMPEL M

IPC: C07D235/06 ,  C07D235/18 ,  A61K27/00

CPC classification number: C07D233/56 ,  C07D235/06 ,  C07D235/18

Abstract: BIS-IMIDAZOLYL-BISPHENYLMETHANE AND PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALTS THEREOF ARE USEFUL AS ANTIMYCOTICS ESPECIALLY AGAINST DERMATOMYCOSIS CAUSED BY TRICHOPHYTON AND MICROSPORIUM SPECIES AND ALSO AGAINST YEAST INFECTIONS OF THE SKIN AND INTERNAL ORGANS.

公开(公告)号：US3719760A

公开(公告)日：1973-03-06

申请号：US7363870

申请日：1970-09-18

Applicant: BAYER AG

Inventor： BUCHEL K ,  GREWE F ,  SCHEINPFLUG H ,  KASPERS H ,  REGEL E

IPC: A01N43/50 ,  C07D233/62 ,  C07D521/00 ,  A01N9/22

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: Plant fungicidal compositions are produced which comprise an amount of a compound of the formula:

WHEREIN Y is the anion of an inorganic or organic acid, sufficient to be effective for killing, combatting or controlling plant fungi, in combination with a solid or liquid diluent or carrier. Methods for killing, combatting or controlling fungal diseases in plants comprise applying to the fungi or to the plant to be protected an effective or toxic amount of the above compound.

公开(公告)号：US3711499A

公开(公告)日：1973-01-16

申请号：US3711499D

申请日：1972-01-17

Applicant: BAYER AG

Inventor： BUCHEL K ,  REGEL E ,  PLEMPEL M

IPC: C07D233/62 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D521/00 ,  C07D49/36

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18

Abstract: N-TRITYL-IMIDAZOLES AND SALTS THEREOF THE FORMULA:

1-(((X)N-PHENYL-)((X'')N''-PHENYL-)((X")N"-PHENYL-)C-),2-R,

4-R1,5-R2-IMIDAZOLE

WHEREIN R, R'' R" ARE HYDROGEN, LOWER ALKYL OR PHENYL, OR R1 AND R2 TOGETHER FORM AN ANELLATED BENZENE RING, X, X'' AND X" ARE ALKYL OF 1 TO 12 CARBON ATOMS OR AN ELECTRO-NEGATIVE MOIETY, AND N, N'' AND N" ARE INTEGER FRON 0 TO 2, OR PHARMACEUTICALLY ACCEPTABLE ACID SALTS THEREOF MAY BE PRODUCED BY REACTING A SILVER SALT OR ALKALI METAL SALT OF AN IMIDAZOLE OF THE FORMULA:

2-R,4-R1,5-R2-IMIDAZOLE

WITH A TRITYL OF THE FORMULA:

(((X)N-PHENYL-),((X'')N-PHENYL-)((X")N"-PHENYL-)C-HAL

WHEREIN THE SUBSTITUENTS ARE AS ABOVE DEFINED AND HAL IS HALOGEN. THESE COMPOUNDS ARE USEFUL AS ANTIMYCOTICS.

公开(公告)号：US3842176A

公开(公告)日：1974-10-15

申请号：US37281473

申请日：1973-06-22

Applicant: BAYER AG

Inventor： REGEL E ,  BUCHEL K ,  PLEMPEL M

IPC: C07D235/06 ,  C07D235/18 ,  A61K27/00

CPC classification number: C07D233/56 ,  C07D235/06 ,  C07D235/18

Abstract: 1. A PHARMACEUTICALLY COMPOSITION USEFUL FOR TREATING FUNGAL INFECTIONS PATHOGENIC TO HUMANS OR ANIMALS WHICH COMPRISES AN ANTIFUNGAL AMOUNT OF A COMPOUND OF THE FORMULA

(2-R1-IMIDAZOL-1-YL)2-C(-PHENYLENE-(X)M)-PHENYLENE-(Y)N

WHEREIN R1 IS HYDROGEN OR ALKYL IOF 1 TO4 CARBON ATOMS; X AND Y ARE NO2; AND M IS 0, 1 OR 2 AND N IS 1 OR 2; OR M IS 1 OR 2 AND N IS 0, 1 OR 2; OR A PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALT THEREOF IN COMBINATION WITH A PHARMACEUTICALLY ACCEPTABLE NONTOXIC INERT DILUENT OR CARRIER.

公开(公告)号：US3836664A

公开(公告)日：1974-09-17

申请号：US37280773

申请日：1973-06-22

Applicant: BAYER AG

Inventor： PLEMPEL M ,  REGEL E ,  BUCHEL K

IPC: C07D235/06 ,  C07D235/18 ,  A61K27/00

CPC classification number: C07D233/56 ,  C07D235/06 ,  C07D235/18

Abstract: BIS-IMIDAZOLYL-BISPHENYLMETHANE AND PHARMACEUTICALLY ACCEPTABLE NON-TOXIC SALTS THEREOF ARE USEFUL AS ANTIMYCOTICS ESPECIALLY AGAINST DERMATOMYCOSIS CAUSED BY TRICHOPHYTON AND MICROSPORIUM SPECIES AND ALSO AGAINST YEAST INFECTIONS OF THE SKIN AND INTERNAL ORGANS

公开(公告)号：US3767668A

公开(公告)日：1973-10-23

申请号：US3767668D

申请日：1972-01-17

Applicant: BAYER AG

Inventor： BUCHEL K ,  REGEL E ,  PLEMPEL M

IPC: C07D233/62 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18 ,  C07D521/00 ,  C07D49/00

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D235/08 ,  C07D235/18

Abstract: N-TRITYL-IMIDAZOLES AND SALTS THEREOF OF THE FORMULA:

(2-R,4-R1,5-R2-IMIDAZOL-1-YL)-C(-C6H4-(X)N)(-C6H4-(X'')N'')-

C6H4-(X")N"

WHEREIN R, R1 AND R2 ARE HYDROGEN, LOWER ALKYL OR PHENYL, OR R1 AND R2 TOGETHER FORM AN ANELLATED BENZENE RING, X, X'' AND X" ARE ALKYL OF 1 TO 12 CARBON ATOMS OR AN ELECTRO-NEGATIVE MOIETY, AND N, N'' AND N" ARE AN INTEGER FROM 0 TO 2, OR PHARMACEUTICALLY ACCEPTABLE ACID SALTS THEREOF MAY BE PRODUCED BY REACTING A SILVER SLAT OR ALKALI METAL SALT OF AN IMIDAZOLE OF THE FORMULA:

2-R,4-R1,5-R2-IMIDAZOLE

WITH A TRITYL HALIDE OF THE FORMULA:

HAL-C(-C6H4-(X)N)(-C6H4-(X'')N'')-C6H4-(X")N"

WHEREIN THE SUBSTIUENTS ARE AS ABOVE DEFINED AND HAL IS HALOGEN. THESE COMPOUNDS ARE USEFUL AS ANTMYCOTICS.

公开(公告)号：US3725549A

公开(公告)日：1973-04-03

申请号：US3725549D

申请日：1971-09-13

Applicant: BAYER AG

Inventor： BUCHEL K ,  REGEL E ,  GREWE F ,  SCHEINPFLUG H ,  KASPERS H

IPC: A01N43/50 ,  C07D521/00 ,  A01N9/22

CPC classification number: C07D231/12 ,  A01N43/50 ,  C07D233/56 ,  C07D249/08

Abstract: Plant fungicial compositions are produced which comprise an amount of a compound of the formula:

WHEREIN R is chloro, bromo or fluoro, or a salt thereof, sufficient to be effective for killing, combatting or controlling plant fungi, in combination with a solid or liquid diluent or carrier. Methods for killing, combatting or controlling fungal diseases in plants comprise applying to the fungi or to the plant to be protected an effective or toxic amount of the above compound.

Abstract translation: 制备植物真菌组合物，其包含一定量的下式的化合物：