公开(公告)号：US3532709A

公开(公告)日：1970-10-06

申请号：US3532709D

申请日：1966-09-20

Applicant: BAYER AG

Inventor： PIEPER GUSTAV ,  BONIN WULF VON ,  GRUNDMANN EKKEHARD

IPC: C07D207/40 ,  C08F8/06 ,  C07D27/10

CPC classification number: C07D207/40 ,  C08F8/06 ,  C08F126/06

公开(公告)号：US3461130A

公开(公告)日：1969-08-12

申请号：US3461130D

申请日：1965-04-28

Applicant: BAYER AG

Inventor： PETERSEN SIEGFRIED ,  GOLD HEINRICH ,  GRUNDMANN EKKEHARD ,  JUHLING LIESELOTTE

IPC: C07D207/32 ,  C07D207/325 ,  C07D213/38 ,  C07D231/12 ,  C07D233/54 ,  C07D249/04 ,  C07D277/28 ,  C07D471/04 ,  C07D521/00 ,  C07D49/18 ,  C07D49/36

CPC classification number: C07D207/325 ,  C07D213/38 ,  C07D231/12 ,  C07D233/56 ,  C07D249/04 ,  C07D249/08 ,  C07D471/04

公开(公告)号：US3682776A

公开(公告)日：1972-08-08

申请号：US3682776D

申请日：1970-02-18

Applicant: BAYER AG

Inventor： GRUNDMANN EKKEHARD ,  SCHMIDT-KASTNER GUNTHER

IPC: A01N1/00 ,  A23L3/3571 ,  A61K35/12 ,  A61K38/55 ,  A61L2/16 ,  A01N1/02 ,  A23B1/14

CPC classification number: A01N1/0226 ,  A23L3/3571 ,  A61K35/12 ,  A61L2/16

Abstract: ORGANS, PARTICULARLY THOSE INTENDED FOR USE IN TRANSPLANTATIONS, SUCH AS THE HUMAN LIVER, AS WELL AS TISSUES AND FOODSTUFFS ARE PRESERVED BY CONTACT WITH BIOLOGICAL PROTEASE-INHIBITORS, SUCH AS KILLIKREIN-TRYPSIN INHIBITOR OR POTATO INHIBITOR, PREFERABLY IN THE FORM OF AN AQUEOUS SOLUTION.

公开(公告)号：US3557140A

公开(公告)日：1971-01-19

申请号：US3557140D

申请日：1968-03-07

Applicant: BAYER AG

Inventor： PIEPER GUSTAV ,  BONIN WULF VON ,  GRUNDMANN EKKEHARD

IPC: C08F8/00 ,  C07D27/10

CPC classification number: C08F222/08 ,  C08F8/06 ,  C08F8/32 ,  C08F8/48 ,  C08F222/40 ,  C08F2222/402 ,  C08F2222/404 ,  C08F2222/406 ,  C08F2800/10 ,  C08F212/08 ,  C08F222/06

Abstract: POLY-N-OXIDES USEFUL IN THE TREATING OF SILICOSIS AND A PROCEDURE FOR MAKING THE SAME AND ADMINISTERING THEM ARE PROVIDED. THE POLY-N-OXIDES HAVE THE FORMULA:

-(Z-(1-(O
-(Z-(1-B,2,5-DI(O=)PYRROLIDIN-3,4-YLENE))M-

IN WHICH Z IS THE MONOMER UNIT OF A VINYL COMPOUND OF THE FORMULA:

-CH2-C(-R1)(-R2)-

WHEREIN R3 IS ALKYLENE, PHENYLENE OR ALKYLPHENYLENE WITH UP TO 7 CARBON ATOMS OF WHICH ONE CH2 GROUP MAY BE REPLACED BY AN OXYGEN ATOM; R4 AND R5 ARE LOWER ALKYL WITH 1 TO 4 CARBON ATOMS WHICH, WHEN LINKED WITH THE NITROGEN ATOM, FORM A 5 TO 7-MEMBERED CYCLIC RING SYSTEM WHICH, IN THE CASE OF A 6-MEMBERED RING, MAY CONTAIN, AS FURTHER HETERO ATOM, OXYGEN, OR A NITROGEN ATOM WHICH IS SUBSTITUTED BY A LOWER ALKYL GROUPF AND THE HETEROCYCLIC RING SYSTEM BEING AROMATIC WHEN NO FURTHER HETERO ATOMS ARE PRESENT; B STANDS FOR AN ALKPIHATIC, CYCLOALIPHATIC, AROMATIC OR HETEROCYCLIC RADICAL OF A PRIMARY MONOAMINE OF UP TO 12 CARBON ATOMS, AND WHICH ARE UNSUBSTITUTED OR SUBSTITUTED BY OH OR LOWER ALKYL; N AND M ARE INTERGERS, WHEREBY THE RATION OF N:M IS 90:10 TO 60:40, THE SUM N+M SIGNIFYING THE POLYMERIZATION DEGREE OF THE M ALEIC ACID ANHYDRIDE COPOLYMER RANGING BETWEEN 50 AND 500.

-R3-N(-R4)-R5

WHICH IS COPOLYMERIZED WITH MALEIC ACID ANHYDRIDE AND WHEREIN R1 AND R2 STAND FOR THE SAME OR DIFFERENT RADICALS SUCH AS HYDROGEN, ALKYL WITH 1-4 CARBON ATOMS, CYCLOALKYL WITH 3 TO 6 CARBON ATOMS, PHENYL OR PHENYL SUBSTITUTED BY LOWER ALKYL, AND WHEREIN ONE OF R1 AND R2 MAY BE ONE OF CN, CONH2, COOH, COOR, OR, OR OCOR IN WHICH R IS ALKYL WITH 1 TO 4 CARBON ATOMS. THE MONOMER UNIT WHICH IS POLYMERIZED WITH MALEIC ANHYDRIDE MAY ALSO BE STYRENE OR ISOBUTYLENE OR ETHYLENE; A-->O STANDS FOR THE RADICAL A OF A PRIMARY-TERTIARY POLYAMINE WHEREIN AT LEAST ONE TERTIARY AMINO GROUP HAS BEEN OXIDIZED TO N-OXIDIZED, AND WHEREIN A HAS THE FORMULA: