公开(公告)号：US3876766A

公开(公告)日：1975-04-08

申请号：US21306671

申请日：1971-12-28

Applicant: BAYER AG

Inventor： FROMMER WERNER ,  PULS WALTER ,  SCHAFER DIETMAR ,  SCHMIDT DELF

IPC: C08B37/00 ,  A61K31/715 ,  A61K35/74 ,  A61K38/55 ,  A61P1/04 ,  A61P3/04 ,  A61P3/08 ,  C12N9/26 ,  C12N9/99 ,  C12P1/04 ,  C12P1/06 ,  C12P19/04 ,  C12R1/01 ,  C12R1/04 ,  C12R1/045 ,  C12R1/62 ,  A61K27/00

CPC classification number: A61K31/70 ,  C12P1/04 ,  C12P1/06 ,  Y10S435/822 ,  Y10S435/896 ,  Y10S435/907

Abstract: This invention relates to inhibitors for glycoside-hydrolases derived from bacteria of the order Actinomycetales, means for their production comprising cultivation of a microorganism of the order Actinomycetales in appropriate nutrient solutions under conditions most favorable to growth and production of the enzyme inhibitor and recovering, as a new product, glycoside-hydrolase enzyme inhibitors, from the culture as well as the use of said enzyme inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating obesity, diabetes, pre-diabetes, gastritis, gastric ulcer, hyperlipidemia (atheriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzymes in the presence of a glycoside-hydrolase enzyme inhibitor for said glycosidehydrolase enzyme derived from a strain of microorganism of the order Actinomycetales. The invention further contemplates the provision of methods for the treatment of indications of the group consisting of obesity, hyperlipidemia (atheriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer, and caries induced by the action of glycoside-hydrolase enzymes and carbohydrates, the improvement which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a strain of microorganism of the order Actinomycetales.