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公开(公告)号：US3887434A
公开(公告)日：1975-06-03
申请号：US36364073
申请日：1973-05-24
Applicant: BAYER AG
Inventor： FROMMER WERNER , RAUENBUSCH ERICH
CPC classification number: C12N9/2408 , Y10S435/941
Abstract: The disclosure relates to a novel process for the microbiological production of the enzyme invertase by culturing yeast strains of the variety Saccharmyces carlsbergensis Hansen under aerobic conditions in an aqueous nutrient medium.
Abstract translation: 本公开涉及通过在有氧条件下在水性营养培养基中培养嘉氏酵母Hansen的酵母菌株来微生物生产酶转化酶的新方法。
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公开(公告)号：US3879546A
公开(公告)日：1975-04-22
申请号：US33672073
申请日：1973-02-28
Applicant: BAYER AG
Inventor： FROMMER WERNER , PULS WALTER , SCHMIDT DELF
CPC classification number: C12P19/04 , C12P19/22 , Y10S435/822
Abstract: This invention relates to the production of saccharase inhibitors in which a polysaccharidic or oligosaccharidic amylase inhibitor is hydrolytically degraded either enzymatically or by acid hydrolysis. The invention also relates to the use of said saccharase inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating adiposity, hyperlipaemia (atherosclerosis), diabetes, pre-diabetes, caries and the like.
Abstract translation: 本发明涉及糖酶抑制剂的生产，其中多糖或寡糖淀粉酶抑制剂通过酶促或通过酸水解进行水解降解。 本发明还涉及所述糖酶抑制剂在药学上可接受的治疗组合物中用于治疗指示肥胖，高脂血症（动脉粥样硬化），糖尿病，前期糖尿病，龋齿等的病症的用途。
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公开(公告)号：US3660239A
公开(公告)日：1972-05-02
申请号：US3660239D
申请日：1969-11-18
Applicant: BAYER AG
Inventor： FROMMER WERNER , WAGNER OTTO
CPC classification number: C12N9/52 , A61K38/00 , Y10S435/816 , Y10S435/886
Abstract: Fibrinolysokinase of good stability is isolated from culture solutions of actinomycetes by heat treatment at a low pH followed by fractional precipitation.
Abstract translation: 通过在低pH下进行热处理，然后分散沉淀，从放线菌培养液中分离具有良好稳定性的纤维蛋白激酶。
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公开(公告)号：US3876766A
公开(公告)日：1975-04-08
申请号：US21306671
申请日：1971-12-28
Applicant: BAYER AG
Inventor： FROMMER WERNER , PULS WALTER , SCHAFER DIETMAR , SCHMIDT DELF
IPC: C08B37/00 , A61K31/715 , A61K35/74 , A61K38/55 , A61P1/04 , A61P3/04 , A61P3/08 , C12N9/26 , C12N9/99 , C12P1/04 , C12P1/06 , C12P19/04 , C12R1/01 , C12R1/04 , C12R1/045 , C12R1/62 , A61K27/00
CPC classification number: A61K31/70 , C12P1/04 , C12P1/06 , Y10S435/822 , Y10S435/896 , Y10S435/907
Abstract: This invention relates to inhibitors for glycoside-hydrolases derived from bacteria of the order Actinomycetales, means for their production comprising cultivation of a microorganism of the order Actinomycetales in appropriate nutrient solutions under conditions most favorable to growth and production of the enzyme inhibitor and recovering, as a new product, glycoside-hydrolase enzyme inhibitors, from the culture as well as the use of said enzyme inhibitors in pharmaceutically acceptable therapeutic compositions in the treatment of conditions indicating obesity, diabetes, pre-diabetes, gastritis, gastric ulcer, hyperlipidemia (atheriosclerosis) and the like. The invention also contemplates the provision of methods of inhibiting the reaction of carbohydrates and glycoside-hydrolase enzymes and particularly carbohydrate-splitting glycoside-hydrolase enzymes of the digestive tract by means of conducting said reaction of said carbohydrates and glycoside-hydrolase enzymes in the presence of a glycoside-hydrolase enzyme inhibitor for said glycosidehydrolase enzyme derived from a strain of microorganism of the order Actinomycetales. The invention further contemplates the provision of methods for the treatment of indications of the group consisting of obesity, hyperlipidemia (atheriosclerosis), diabetes, pre-diabetes, gastritis, gastric ulcer, duodenal ulcer, and caries induced by the action of glycoside-hydrolase enzymes and carbohydrates, the improvement which comprises employing an enzyme inhibitor for glycoside-hydrolase enzymes produced by a strain of microorganism of the order Actinomycetales.
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