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公开(公告)号：US20230065629A1
公开(公告)日：2023-03-02
申请号：US17519329
申请日：2021-11-04
发明人： Anja GIESE , Jürgen KLAR , Alexander Helmut Michael EHRMANN , Jens WILLWACHER , David ENGEL , Andre Philippe DIESKAU , Antje KAHNERT , Alexey GROMOV , Carsten SCHMECK , Niels LINDNER , Thomas MÜLLER , Anna Lena ANDREEVSKI , Jan DREHER , Karl COLLINS
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200055842A1
公开(公告)日：2020-02-20
申请号：US16341410
申请日：2017-10-09
发明人： Anja GIESE , Jürgen KLAR , Alexander Helmut Michael EHRMANN , Jens WILLWACHER , David ENGEL , Andre Philippe DIESKAU , Antje KAHNERT , Alexey GROMOV , Carsten SCHMECK , Niels LINDNER , Thomas MÜLLER , Anna Lena ANDREEVSKI , Jan DREHER , Karl COLLINS
IPC分类号： C07D403/14 , C07D401/14 , C07D487/04 , C07D405/14 , C07D413/14
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20170253602A1
公开(公告)日：2017-09-07
申请号：US15529043
申请日：2015-11-23
发明人： Andreas SCHALL , Jürgen KLAR , Mario LOBELL , Hartmut SCHIROK , Joachim TELSER , Steffen MÜLLER , Dirk BROHM , Hans BRIEM , Hannah JÖRIßEN , Joerg KELDENICH (deceased) , Michael BÖTTGER , Georges DEGENFELD VON , Thomas SCHLANGE , Ulf BÖMER , Niels LINDNER , Hanna EILKEN , Dmitrij HRISTODOROV , Pierre WASNAIRE , Kersten Matthias GERICKE , Lars BÄRFACKER
IPC分类号： C07D487/04 , A61K39/395 , A61K31/5513
CPC分类号： C07D487/04 , A61K31/5513 , A61K39/39558
摘要： The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：US20160272637A1
公开(公告)日：2016-09-22
申请号：US15032212
申请日：2014-10-28
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Henrik TELLER , Eloisa JIMENEZ NUNEZ , Hartmut SCHIROK , Jürgen KLAR
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US20170283412A1
公开(公告)日：2017-10-05
申请号：US15513853
申请日：2015-09-22
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRAßBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Henrik TELLER , Eloisa JIMÉNEZ NÚNEZ , Hartmut SCHIROK , Jürgen KLAR , Mario LOBELL
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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6.发明申请Substituted Oxopyridine Derivatives and Use Thereof in the Treatment of Cardiovascular Disorders 有权取代的氧吡啶衍生物及其用途治疗心血管疾病公开(公告)号：US20160052884A1
公开(公告)日：2016-02-25
申请号：US14780925
申请日：2014-03-27
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRAßBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Hartmut SCHIROK , Jürgen KLAR , Eloisa JIMENEZ NUNEZ
IPC分类号： C07D213/64 , C07D413/12 , C07D213/84 , C07D409/06 , C07D405/06 , C07D413/14 , C07D417/12 , C07D401/12 , C07D213/69
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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7.发明申请公开(公告)号：US20180086742A1
公开(公告)日：2018-03-29
申请号：US15786352
申请日：2017-10-17
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Harmut SCHIROK , Jürgen KLAR , Eloisa Jimenez NUNEZ
IPC分类号： C07D405/06 , C07D213/84 , C07D213/85 , C07D401/12 , C07D413/14 , C07D413/12 , C07D417/12 , C07D213/64 , C07D213/69 , C07D409/06
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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8.发明申请SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS 审中-公开取代的碘吡啶衍生物及其在治疗心血管疾病中的应用公开(公告)号：US20160368903A1
公开(公告)日：2016-12-22
申请号：US15256608
申请日：2016-09-04
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Hartmut SCHIROK , Jürgen KLAR , Eloisa Jimenez NUNEZ
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US20160318866A1
公开(公告)日：2016-11-03
申请号：US15106285
申请日：2014-12-16
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Mark Jean GNOTH , Herbert HIMMEL , Raimund KAST , Joerg KELDENICH , Jürgen KLAR , Andreas KNORR , Dieter LANG , Niels LINDNER , Carsten SCHMECK , Rudolf SCHOHE-LOOP , Hanna TINEL , Hubert TRÜBEL , Frank WUNDER
IPC分类号： C07D211/10 , C07D211/42 , C07D211/22 , A61K45/06 , C07D401/14 , C07D413/14 , C07D405/14 , C07D211/60 , A61K31/4545
CPC分类号： C07D211/10 , A61K31/4545 , A61K45/06 , C07D211/16 , C07D211/22 , C07D211/42 , C07D211/60 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
摘要翻译： 本发明涉及新的取代的二哌啶基衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病溃疡，特别是用于促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。
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公开(公告)号：US20190185466A1
公开(公告)日：2019-06-20
申请号：US16192314
申请日：2018-11-15
发明人： Adam James DAVENPORT , Nico BRÄUER , Oliver Martin FISCHER , Andrea ROTGERI , Antje ROTTMANN , Ioana NEAGOE , Jens NAGEL , Anne-Marie GODINHO-COELHO , Jürgen KLAR
IPC分类号： C07D417/12 , A61P13/10 , C07D498/08 , C07D471/08 , A61K31/5377 , A61P31/04 , C07D417/14 , A61P13/00 , A61P29/00 , A61P25/16 , A61P31/18 , A61P25/28
摘要： The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.
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