公开(公告)号：US20140293734A1

公开(公告)日：2014-10-02

申请号：US14278527

申请日：2014-05-15

Applicant: BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Jörg KAULING ,  Helmut BROD ,  Sebastian SCHMIDT ,  Martin POGGEL ,  Björn FRAHM ,  Reinhold ROSE

IPC: B01J19/28 ,  B01F11/00

CPC classification number: B01J19/28 ,  B01F3/04269 ,  B01F11/0002 ,  B01F11/0008 ,  B01F13/0018 ,  B01F13/0032 ,  B01F15/00733 ,  B01F15/0085 ,  B01F15/00915 ,  B01F15/065 ,  B01F15/066 ,  B01F2003/04361 ,  B01J19/123 ,  B01J19/285 ,  B01J2219/0025 ,  B01J2219/00761 ,  B01J2219/185 ,  B01J2219/192 ,  C12M23/14 ,  C12M23/28 ,  C12M27/02 ,  C12M27/10

Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.

Abstract translation: 本发明涉及一种围绕其固定的，优选垂直的轴以振荡旋转方式驱动的反应器，优选用于生物技术和制药应用。 通过其混合，悬浮，气态物质运输，传热，照射和颗粒保留的工艺增强性能，确保了工业规模的适用性。 没有轴封成功的反应器相对于无菌技术可以特别稳定的生产，避免了当反应器被构造为一次性反应器时所需的清洁和清洁验证。

公开(公告)号：US20140080213A1

公开(公告)日：2014-03-20

申请号：US14047531

申请日：2013-10-07

Applicant: BAYER INTELLECTUAL PROPERTY GMBH

Inventor： Jörg KAULING ,  Helmut BROD ,  Sebastian SCHMIDT ,  Martin POGGEL ,  Björn FRAHM ,  Reinhold ROSE

IPC: C12M1/00

CPC classification number: B01J19/28 ,  B01F3/04269 ,  B01F11/0002 ,  B01F11/0008 ,  B01F13/0018 ,  B01F13/0032 ,  B01F15/00733 ,  B01F15/0085 ,  B01F15/00915 ,  B01F15/065 ,  B01F15/066 ,  B01F2003/04361 ,  B01J19/123 ,  B01J19/285 ,  B01J2219/0025 ,  B01J2219/00761 ,  B01J2219/185 ,  B01J2219/192 ,  C12M23/14 ,  C12M23/28 ,  C12M27/02 ,  C12M27/10

Abstract: The invention relates to a reactor driven in an oscillatory-rotary manner about its fixed, preferably vertical, axis, for preferably biotechnological and pharmaceutical applications. By means of its process-intensifying properties for mixing, suspension, gaseous material transport, heat transfer, irradiation and particle retention, the applicability on the industrial scale is ensured. The reactor which succeeds without a shaft seal permits particularly robust production with respect to sterile technique with avoidance of cleaning and cleaning validation required when the reactor is constructed as a single-use reactor.