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公开(公告)号:US20180008536A1
公开(公告)日:2018-01-11
申请号:US15544326
申请日:2016-01-20
申请人: BAYER OY
发明人: Harri JUKARAINEN , Jyrki PIHLAJA , Svante HOLMBERG , Tuula VALO , Anu-Liisa HONKA , Jenny HOLLAENDER
IPC分类号: A61K9/00 , A61K9/70 , A61K31/405 , A61K47/34 , A61K47/32 , A61K31/567 , B29L31/00 , B29K23/00 , B29K105/00
CPC分类号: A61K9/0039 , A61K9/70 , A61K31/405 , A61K31/567 , A61K47/32 , A61K47/34 , B29C64/106 , B29C64/118 , B29K2023/083 , B29K2105/0035 , B29L2031/753 , B33Y10/00 , B33Y80/00
摘要: The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material. A further object of the invention is to fabricate drug-containing T-intrauterine systems (I US) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5-40 wt %, namely 5%, 15% and 30% wt %: of Indomethacin.