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公开(公告)号：US20210261541A1
公开(公告)日：2021-08-26
申请号：US17161201
申请日：2021-01-28
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20190241562A1
公开(公告)日：2019-08-08
申请号：US16317322
申请日：2017-07-04
发明人： Henrik TELLER , Melissa BOULTADAKIS ARAPINIS , Alexandros VAKALOPOULOS , Anne-Sophie REBSTOCK , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Klaus MÜNTER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/04 , A61P13/12 , A61P9/06
摘要： The present application relates to novel 7-substituted 1-pyridylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20220089591A1
公开(公告)日：2022-03-24
申请号：US17161186
申请日：2021-01-28
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20190263805A1
公开(公告)日：2019-08-29
申请号：US16333079
申请日：2017-09-06
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximilian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61K45/06 , C07D519/00 , C07D491/107 , A61P9/06 , A61K31/551 , A61K31/4375
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20170240566A1
公开(公告)日：2017-08-24
申请号：US15503578
申请日：2015-08-25
发明人： Alexandros VAKALOPOULOS , Gaelle VALOT , Markus FOLLMANN , Damian BROCKSCHNIEDER , Johannes-Peter STASCH , Tobias MARQUARDT , Adrian TERSTEEGEN , Frank WUNDER , Lisa DIETZ , Dieter LANG , Ursula KRENZ
IPC分类号： C07D519/00 , A61K31/519 , C07D487/04 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06 , C07D487/04
摘要： The present application relates to novel amino-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20170233413A1
公开(公告)日：2017-08-17
申请号：US15503448
申请日：2015-08-25
发明人： Walter HÜBSCH , Alexandros VAKALOPOULOS , Markus FOLLMANN , Gaelle VALOT , Johannes-Peter STASCH , Damian BROCKSCHNIEDER , Tobias MARQUARDT , Frank WUNDER , Adrian TERSTEEGEN , Lisa DIETZ , Dieter LANG , Niels LINDNER
IPC分类号： C07D519/00 , C07D487/04 , A61K9/08 , A61K31/519 , A61K9/20 , A61K9/00
CPC分类号： C07D519/00 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/519 , C07D471/04 , C07D487/04
摘要： The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![6-CHLORINE-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE CARBOXAMIDES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE STIMULATORS](/abs-image/US/2017/04/13/US20170101407A1/abs.jpg.150x150.jpg)
7.发明申请公开(公告)号：US20170101407A1
公开(公告)日：2017-04-13
申请号：US15308200
申请日：2015-04-29
发明人： Alexandros VAKALOPOULOS , Markus FOLLMANN , Johannes-Peter STASCH , Frank WUNDER , Tobias MARQUARDT , Lisa DIETZ , Dieter LANG , Volkhart Min-Jian LI
IPC分类号： C07D471/04 , A61K31/437 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： The present application relates to novel 6-chloro-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
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![SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE](/abs-image/US/2017/03/02/US20170057954A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170057954A1
公开(公告)日：2017-03-02
申请号：US15120343
申请日：2015-03-19
发明人： Alexandros VAKALOPOULOS , Gaelle VALOT , Niels LINDNER , Markus FOLLMANN , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Gorden REDLICH , Lisa DIETZ , Volkhart Min-Jian Ll
IPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K31/55 , A61K31/444 , A61K31/506 , A61K31/498 , A61K31/4709 , A61K45/06 , A61K31/496
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法，其用途，单独或组合用于治疗和/或预防疾病，以及使用 用于生产用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
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9.发明申请ESTRA-1,3,5(10),16-TETRAENE-3-CARBOXAMIDES FOR INHIBITION OF 17.BETA.-HYDROXYSTEROID DEHYDROGENASE (AKR1 C3) 有权ESTRA-1,3,5（10），16-TETRAENE-3-CARBOXAMIDES，用于抑制17.BETA-羟基脱氢酶脱氢酶（AKR1 C3）公开(公告)号：US20160024142A1
公开(公告)日：2016-01-28
申请号：US14770444
申请日：2014-02-18
发明人： Ulrich BOTHE , Matthias BUSEMANN , Naomi BARAK , Andrea ROTGERI , Oliver Martin FISCHER , Tobias MARQUARDT
CPC分类号： C07J43/003 , A61K31/58 , A61K45/06
摘要： The invention relates to AKR1C3 inhibitors of formula (I) and to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of bleeding disorders and endometriosis.
摘要翻译： 本发明涉及式（I）的AKR1C3抑制剂及其制备方法及其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途，特别是 出血性疾病和子宫内膜异位症。
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公开(公告)号：US20220023246A1
公开(公告)日：2022-01-27
申请号：US17494421
申请日：2021-10-05
IPC分类号： A61K31/216 , A61K45/06 , A61K31/41 , A61K31/506 , A61K31/519
摘要： The present invention relates to stimulators and activators of soluble guanylate cyclase in combination with an inhibitor of neutral endopeptidase and/or angiotensin AII antagonists and the use thereof for the treatment and/or prophylaxis of cardiovascular disorders, for example heart failure with preserved ejection fraction or heart failure with reduced ejection fraction, renal disorders, for example chronic kidney failure, urological disorders, lung disorders, disorders of the central nervous system, for regulation of cerebral perfusion, for example in the event of vascular cerebral states of dementia, for the treatment and/or prophylaxis of fibrotic disorders and other disease symptoms (e.g. end organ damage affecting the brain, kidney or heart).
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