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公开(公告)号：US20210261541A1
公开(公告)日：2021-08-26
申请号：US17161201
申请日：2021-01-28
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20190241562A1
公开(公告)日：2019-08-08
申请号：US16317322
申请日：2017-07-04
发明人： Henrik TELLER , Melissa BOULTADAKIS ARAPINIS , Alexandros VAKALOPOULOS , Anne-Sophie REBSTOCK , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Klaus MÜNTER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/04 , A61P13/12 , A61P9/06
摘要： The present application relates to novel 7-substituted 1-pyridylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20220144848A1
公开(公告)日：2022-05-12
申请号：US17416274
申请日：2019-12-18
发明人： Susanne ROEHRIG , Sebastian ESSIG , Pascal ELLERBROCK , Sonja ANLAUF , Thomas NEUBAUER , Alexander HILLISCH , Katharina MEIER , Stefan HEITMEIER , Adrian TERSTEEGEN , Martina SCHAFER , Jan STAMPFUSS , Dieter LANG , Eloisa JIMENEZ NUNEZ , Jens ACKERSTAFF , Henrik TELLER , Zengqiang ZOU , Ping LIU , Xianghai MENG , Frank LESSMANN
IPC分类号： C07D491/044
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular vascular disorders, preferably thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications.
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公开(公告)号：US20220089591A1
公开(公告)日：2022-03-24
申请号：US17161186
申请日：2021-01-28
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20190263805A1
公开(公告)日：2019-08-29
申请号：US16333079
申请日：2017-09-06
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximilian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61K45/06 , C07D519/00 , C07D491/107 , A61P9/06 , A61K31/551 , A61K31/4375
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20160272637A1
公开(公告)日：2016-09-22
申请号：US15032212
申请日：2014-10-28
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Henrik TELLER , Eloisa JIMENEZ NUNEZ , Hartmut SCHIROK , Jürgen KLAR
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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7.发明申请公开(公告)号：US20180086742A1
公开(公告)日：2018-03-29
申请号：US15786352
申请日：2017-10-17
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Harmut SCHIROK , Jürgen KLAR , Eloisa Jimenez NUNEZ
IPC分类号： C07D405/06 , C07D213/84 , C07D213/85 , C07D401/12 , C07D413/14 , C07D413/12 , C07D417/12 , C07D213/64 , C07D213/69 , C07D409/06
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US20170298052A1
公开(公告)日：2017-10-19
申请号：US15513988
申请日：2015-09-22
发明人： Susanne RÖHRIG , Eloisa JIMENEZ NUNEZ , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Henrik TELLER , Alexander HILLISCH , Stefan HEITMEIER , Martina Victoria SCHMIDT , Jan STAMPFUß
IPC分类号： C07D413/06 , C07D401/06 , C07D213/69 , C07D405/06 , C07D213/64
CPC分类号： C07D413/06 , A61P7/10 , A61P27/02 , C07D213/64 , C07D213/69 , C07D213/85 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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9.发明申请SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS 审中-公开取代的碘吡啶衍生物及其在治疗心血管疾病中的应用公开(公告)号：US20160368903A1
公开(公告)日：2016-12-22
申请号：US15256608
申请日：2016-09-04
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Hartmut SCHIROK , Jürgen KLAR , Eloisa Jimenez NUNEZ
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US20170283412A1
公开(公告)日：2017-10-05
申请号：US15513853
申请日：2015-09-22
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRAßBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Henrik TELLER , Eloisa JIMÉNEZ NÚNEZ , Hartmut SCHIROK , Jürgen KLAR , Mario LOBELL
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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