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    Fatty acid treatment for cardiac patients
    1.
    发明授权
    Fatty acid treatment for cardiac patients 有权

    公开(公告)号：US10071070B2

    公开(公告)日：2018-09-11

    申请号：US15587236

    申请日：2017-05-04

    Applicant: Baylor Research Institute

    Inventor： Charles R. Roe

    IPC: A61K31/20 ,  A61K31/19 ,  A61K31/194 ,  A61K31/23

    CPC classification number: A61K31/20 ,  A61K31/19 ,  A61K31/194 ,  A61K31/23

    Abstract: A method of treating patients in need of treatment for a cardiac disorder has been found which comprises administering to the patient a seven carbon fatty acid compound or derivative thereof, wherein the compound or derivative thereof is able to readily enter the mitochondrion without special transport enzymes. A dietary formulation suitable for treatment of heart tissue in cardiac or surgical patients has been found which comprises a seven-carbon fatty acid chain, wherein the seven-carbon fatty acid chain is characterized by the ability to transverse the inner mitochondrial membrane by a transport mechanism which does not require carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, or carnitine/acylcarnitine translocase and the ability to undergo mitochondrial β-oxidation, and wherein the compound is selected from the group consisting of n-heptanoic acid or a derivative thereof, a triglyceride comprising n-heptanoic acid or a derivative thereof, and triheptanoin or a derivative thereof.

    Fatty acid treatment for cardiac patients
    3.
    发明授权
    Fatty acid treatment for cardiac patients 有权
    心脏病患者的脂肪酸治疗

    公开(公告)号：US09402822B2

    公开(公告)日：2016-08-02

    申请号：US14523810

    申请日：2014-10-24

    Applicant: Baylor Research Institute

    Inventor： Charles R. Roe

    IPC: A61K31/194 ,  A61K31/19 ,  A61K31/20 ,  A61K31/23

    CPC classification number: A61K31/20 ,  A61K31/19 ,  A61K31/194 ,  A61K31/23

    Abstract: A method of treating patients in need of treatment for a cardiac disorder has been found which comprises administering to the patient a seven carbon fatty acid compound or derivative thereof, wherein the compound or derivative thereof is able to readily enter the mitochondrion without special transport enzymes. A dietary formulation suitable for treatment of heart tissue in cardiac or surgical patients has been found which comprises a seven-carbon fatty acid chain, wherein the seven-carbon fatty acid chain is characterized by the ability to transverse the inner mitochondrial membrane by a transport mechanism which does not require carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, or carnitine/acylcarnitine translocase and the ability to undergo mitochondrial β-oxidation, and wherein the compound is selected from the group consisting of n-heptanoic acid or a derivative thereof, a triglyceride comprising n-heptanoic acid or a derivative thereof, and triheptanoin or a derivative thereof.

    Abstract translation: 已经发现治疗需要治疗心脏病症的患者的方法包括向患者施用七碳脂肪酸化合物或其衍生物，其中所述化合物或其衍生物能够容易地进入线粒体而没有特殊的转运酶。 已经发现适合于治疗心脏或外科手术患者心脏组织的膳食制剂包括七碳脂肪酸链，其中七碳脂肪酸链的特征在于通过运输机制横向内线粒体膜的能力 其不需要肉碱棕榈酰转移酶I，肉碱棕榈酰转移酶II或肉碱/酰基肉毒碱转位酶和进行线粒体β-氧化的能力，并且其中所述化合物选自正庚酸或其衍生物，甘油三酯包含 正庚酸或其衍生物，三庚醇或其衍生物。

    NUTRIENT SENSOR
    4.
    发明申请
    NUTRIENT SENSOR 审中-公开
    营养传感器

    公开(公告)号：US20130197084A1

    公开(公告)日：2013-08-01

    申请号：US13794493

    申请日：2013-03-11

    Applicant: BAYLOR RESEARCH INSTITUTE

    Inventor： Charles R. Roe

    IPC: A61K31/20

    CPC classification number: A61K31/20 ,  A61K31/19 ,  A61K31/22 ,  A61K31/23

    Abstract: The present invention includes compositions and methods for treating the effects of catabolism in a patient by providing the patient with an amount of an odd-chain fatty acid sufficient to increase the intracellular ratio of AMP to ATP and reduce the activity of AMPK.

    Abstract translation: 本发明包括通过向患者提供足以增加AMP与ATP的细胞内比例并降低AMPK活性的奇数链脂肪酸的量来治疗患者分解代谢作用的组合物和方法。

    FATTY ACID TREATMENT FOR CARDIAC PATIENTS
    5.
    发明申请
    FATTY ACID TREATMENT FOR CARDIAC PATIENTS 有权
    脂肪酸治疗心脏病患者

    公开(公告)号：US20150105585A1

    公开(公告)日：2015-04-16

    申请号：US14523810

    申请日：2014-10-24

    Applicant: Baylor Research Institute

    Inventor： Charles R. Roe

    IPC: A61K31/194 ,  A61K31/19

    CPC classification number: A61K31/20 ,  A61K31/19 ,  A61K31/194 ,  A61K31/23

    Abstract: A method of treating patients in need of treatment for a cardiac disorder has been found which comprises administering to the patient a seven carbon fatty acid compound or derivative thereof, wherein the compound or derivative thereof is able to readily enter the mitochondrion without special transport enzymes. A dietary formulation suitable for treatment of heart tissue in cardiac or surgical patients has been found which comprises a seven-carbon fatty acid chain, wherein the seven-carbon fatty acid chain is characterized by the ability to transverse the inner mitochondrial membrane by a transport mechanism which does not require carnitine palmitoyltransferase I, carnitine palmitoyltransferase II, or carnitine/acylcarnitine translocase and the ability to undergo mitochondrial β-oxidation, and wherein the compound is selected from the group consisting of n-heptanoic acid or a derivative thereof, a triglyceride comprising n-heptanoic acid or a derivative thereof, and triheptanoin or a derivative thereof.

    Abstract translation: 已经发现治疗需要治疗心脏病症的患者的方法包括向患者施用七碳脂肪酸化合物或其衍生物，其中所述化合物或其衍生物能够容易地进入线粒体而没有特殊的转运酶。 已经发现适合于治疗心脏或外科手术患者心脏组织的膳食制剂包括七碳脂肪酸链，其中七碳脂肪酸链的特征在于通过运输机制横向内线粒体膜的能力 其不需要肉碱棕榈酰转移酶I，肉碱棕榈酰转移酶II或肉碱/酰基肉毒碱转位酶，并且具有进行线粒体和氧化的能力，并且其中所述化合物选自正庚酸或其衍生物，甘油三酯 包括正庚酸或其衍生物，和三庚醇或其衍生物。

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