专利检索 ap:("BEAM THERAPEUTICS INC.") AND inv:"Apurva Govande" 第 1 页

1.

发明公开
CHIMERIC PSEUDOTYPED RECOMBINANT RABIES VIRUS 审中-公开

公开(公告)号：US20240327802A1

公开(公告)日：2024-10-03

申请号：US18428690

申请日：2024-01-31

申请人： BEAM THERAPEUTICS INC.

发明人： ChieYu Lin , Fei Ran , Apurva Govande

IPC分类号： C12N7/00 , A61K48/00 , C07K14/005 , C12N9/22 , C12N15/11 , C12N15/86

CPC分类号： C12N7/00 , A61K48/0041 , C07K14/005 , C12N9/22 , C12N15/11 , C12N15/86 , C12N2310/20 , C12N2760/20021 , C12N2760/20022 , C12N2760/20043

摘要： Provided herein are chimeric pseudotyped recombinant RABV particles, wherein the chimeric envelope protein comprises, from N-terminus to C-terminus, a non-RABV envelope protein ectodomain, a non-RABV envelope protein transmembrane domain, and a RABV C-terminal domain. Also provided are methods for their use in delivering a transgene into a target cell.