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公开(公告)号：US10539581B2
公开(公告)日：2020-01-21
申请号：US15331638
申请日：2016-10-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Alireza Ebrahim , Karl De Vore , Christopher Spates
Abstract: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.
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公开(公告)号：US20160054339A1
公开(公告)日：2016-02-25
申请号：US14831765
申请日：2015-08-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC: G01N33/78
Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.
Abstract translation: 为最终用户提供诊断测量程序的方法，以制备具有所需分析物回收率的质量控制，估计已经制备的质量控制的回收率，并比较估计和测量的回收率。 为了制备含有特定分析物的质量控制，可以通过相关因子来缩放分析物测量程序的期望回收，以获得质量控制中分析物的目标标称浓度。 或者，质量控制中的分析物的标称浓度可以通过相关因子来缩放，以获得对分析物的测量程序的预测回收。 相关因子可以基于先前使用测量程序获得的恢复数据和可选的一个或多个参考程序，并且可以使用这些数据的回归分析来计算。 每个质量控制可以通过将包含目标分析物的许多固体珠溶解在一定体积的基质中来制备。
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公开(公告)号：US20230031105A1
公开(公告)日：2023-02-02
申请号：US17962360
申请日：2022-10-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： James Barry , Vishal Mehra , Alireza Ebrahim
Abstract: A reagent sleeve system such as can be used with various analyzers using chemical phenomena, analyzers and methods of using the reagent sleeve system and analyzer are described. The reagent sleeve system can include a reagent sleeve; and a plurality of removable reagent reservoirs located within the reagent sleeve, wherein each of the plurality of removable reagent reservoirs comprises a respective peripheral wall, and first and second end walls, whereby each of the plurality of removable reagent reservoirs contains a reagent located therein, and the first end wall is pierceable by a reagent extractor, and the reagent sleeve comprises a peripheral wall that encompasses the plurality of removable reagent reservoirs and holds the plurality of reagent reservoirs for sequential use.
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公开(公告)号：US11385245B2
公开(公告)日：2022-07-12
申请号：US16880705
申请日：2020-05-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Alireza Ebrahim , Karl De Vore , Christopher Spates
Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.
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公开(公告)号：US20200284809A1
公开(公告)日：2020-09-10
申请号：US16880705
申请日：2020-05-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Alireza Ebrahim , Karl De Vore , Christopher Spates
Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.
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Patent Agency Ranking
公开(公告)号：US10697981B2
公开(公告)日：2020-06-30
申请号：US15849514
申请日：2017-12-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Alireza Ebrahim , Karl De Vore , Christopher Spates
Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.
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公开(公告)号：US09885728B2
公开(公告)日：2018-02-06
申请号：US14831765
申请日：2015-08-20
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Alireza Ebrahim , Karl De Vore , Christopher Spates
Abstract: Methods are provided for end users of diagnostic measurement procedures to prepare quality controls having desired analyte recoveries, estimate recoveries of quality controls already prepared, and compare estimated and measured recoveries. To prepare a quality control containing a particular analyte, a desired recovery of a measurement procedure for the analyte can be scaled by a correlation factor to obtain a target nominal concentration of the analyte in the quality control. Alternatively, the nominal concentration of an analyte in a quality control can be scaled by a correlation factor to obtain a predicted recovery of a measurement procedure for the analyte. The correlation factors can be based on recovery data previously obtained using the measurement procedure and optionally one or more reference procedures, and can be calculated using regression analysis of these data. Each quality control can be prepared by dissolving a number of solid beads containing the analyte(s) of interest in a volume of base matrix.
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公开(公告)号：US20170122970A1
公开(公告)日：2017-05-04
申请号：US15331638
申请日：2016-10-21
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC: G01N33/96
Abstract: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.
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公开(公告)号：US09599543B2
公开(公告)日：2017-03-21
申请号：US14938780
申请日：2015-11-11
Applicant: Bio-Rad Laboratories, Inc. QSD
Inventor： Alireza Ebrahim , Christopher Spates , Karl De Vore
CPC classification number: G01N1/28 , C12Q1/32 , G01N21/91 , G01N33/96 , G01N2001/2893 , G01N2333/765 , G01N2496/00 , G01N2496/80
Abstract: Solid beads each containing a selected quantity of analyte are combined and a liquid base matrix that contains attributes of a biological fluid that is to be assayed, together constitute a kit from which a laboratory technician can, at the point of use, prepare a liquid control for a particular analyte, and preferably a series of such controls at different levels of the same analyte customized for a particular assay.
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公开(公告)号：US20140134597A1
公开(公告)日：2014-05-15
申请号：US14062351
申请日：2013-10-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Alireza Ebrahim , Karl De Vore , Christopher Spates
IPC: C12N5/078
CPC classification number: G01N33/721 , G01N33/5094
Abstract: Intact erythrocytes with selected and often elevated levels of hemoglobin A1c (HbA1c) for use as quality controls for HbA1c assays and assay instruments are prepared by hypotonic dialysis of erythrocytes from a healthy mammal to permeabilize the erythrocyte membranes, infusion of the permeabilized erythrocytes with hemoglobin A1c, and de-permeabilization of the infused erythrocytes. Quality controls of essentially any level of HbA1c can be prepared in this manner and once prepared will be useful for monitoring the entire assay procedure, including the lysis of the erythrocytes in a typical sample.
Abstract translation: 通过对来自健康哺乳动物的红细胞进行低渗透析以透过红细胞膜，用血红蛋白A1c输注透化的红细胞，制备具有选定且经常升高的血红蛋白A1c（HbA1c）水平的完整红细胞，用于HbA1c测定和测定仪器的质量控制 ，以及输注红细胞的不透性化。 可以以这种方式制备基本上任何水平的HbA1c的质量控制，一旦制备将用于监测整个测定程序，包括典型样品中红细胞的裂解。
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