公开(公告)号：US20240207325A1

公开(公告)日：2024-06-27

申请号：US18554136

申请日：2022-04-08

Applicant: BIOCRINE AB

Inventor： Per-Olof Berggren ,  Ingo Leibiger ,  Barbara Leibiger

IPC: A61K35/39 ,  A61K38/22 ,  A61K38/26 ,  A61P3/04 ,  C07K14/575 ,  C07K14/605 ,  C12N5/071 ,  C12N15/86

CPC classification number: A61K35/39 ,  A61K38/2264 ,  A61K38/26 ,  A61P3/04 ,  C07K14/5759 ,  C07K14/605 ,  C12N5/0677 ,  C12N15/86 ,  C12N2533/50 ,  C12N2710/10043

Abstract: Engineered pancreatic islet organoids encoding a polypeptide not endogenously expressed in pancreatic islet cells and methods for using them to treat diseases and disorders associated with reduced or absent expression of the polypeptide are provided.