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公开(公告)号：US20230146591A1
公开(公告)日：2023-05-11
申请号：US18056279
申请日：2022-11-17
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K16/2827 , C07K2317/31 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The present invention relates to a bispecific molecule comprising at least one anti-CD38 domain and at least one anti-PD-L1 domain, which are capable of simultaneous binding to CD38 and PD-L1 antigens, respectively.
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公开(公告)号：US20200299413A1
公开(公告)日：2020-09-24
申请号：US16498421
申请日：2018-03-27
摘要： The invention relates to multispecific antibody constructs comprising Fab fragments having a particular set of mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
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公开(公告)号：US20240209118A1
公开(公告)日：2024-06-27
申请号：US18589695
申请日：2024-02-28
发明人： EUGENE ZHUKOVSKY , OLIVIER LEGER
CPC分类号： C07K16/468 , C07K16/2827 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55
摘要： The present invention relates to a mutant polypeptide linker for preparing multispecific antibodies, multispecific antibodies, and methods for producing multispecific antibodies.
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公开(公告)号：US20200010559A1
公开(公告)日：2020-01-09
申请号：US16088181
申请日：2017-03-27
IPC分类号： C07K16/28
摘要： The present invention relates to a bispecific molecule comprising at least one anti-CD38 domain and at leak one anti-PD-L1 domain, which are capable of simultaneous binding to CD38 and PD-L1 antigens, respectively.
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公开(公告)号：US20190330377A1
公开(公告)日：2019-10-31
申请号：US16476624
申请日：2018-01-09
发明人： EUGENE ZHUKOVSKY , OLIVIER LEGER
摘要： The present invention relates to a mutant polypeptide linker for preparing multispecific antibodies, said multispecific antibodies, and methods for producing said multispecific antibodies.
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公开(公告)号：US20190153104A1
公开(公告)日：2019-05-23
申请号：US16096698
申请日：2017-04-28
申请人： BIOMUNEX PHARMACEUTICALS , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE MONTPELLIER , INSTITUT REGIONAL DU CANCER DE MONTPELLIER (ICM)
发明人： EUGENE ZHUKOVSKY , OLIVIER LEGER , PIERRE-EMMANUEL GERARD , ANDRE PELEGRIN , CHRISTEL LARBOURET
摘要： The present disclosure relates to bispecific antibodies targeting EGFR and HER2, and methods for the production of these antibodies. The bispecific antibodies consist of one complete antibody on which two VH-VL chains are attached via a linker to each NH terminal region of both VH chains of the antibody. The bispecific antibodies constructed use the amino acid sequences of the heavy chain (VH) and the light chain (VL) variable regions of two monoclonal antibodies targeting EGFR and HER2, namely cetuximab and trastuzumab, respectively.
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