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公开(公告)号：US12263215B2
公开(公告)日：2025-04-01
申请号：US17209926
申请日：2021-03-23
Applicant: BIONTECH SE
Inventor： Steve Pascolo
Abstract: The present invention relates to particles comprising RNA, in which the RNA is associated with a cationic polymer or lipid or with both a cationic polymer and lipid, wherein the RNA comprises a cytotoxic nucleotide or cytotoxic nucleotide analog and/or the RNA is covalently attached to a cytotoxin, pharmaceutical compositions containing said particles and pharmaceutical uses of the particles and pharmaceutical compositions. The particles of the present invention are particularly useful as an immunostimulating medicament capable to block proliferation or induce death in dividing cells such as tumor cells.
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公开(公告)号：US10729785B2
公开(公告)日：2020-08-04
申请号：US15309686
申请日：2014-05-19
Applicant: BioNTech SE
Inventor： Steve Pascolo
IPC: A61K48/00 , C12N15/88 , A61K47/69 , A61K47/58 , A61K47/64 , A61K9/16 , A61K38/17 , A61K41/00 , A61K47/32 , A61K47/42
Abstract: The present invention relates to particles comprising protamine, RNA and at least one endosome destabilizing agent, to methods of their production and to pharmaceutical compositions or kits containing the particles. It further relates to particles comprising protamine and RNA for use in methods of treatment or prevention of diseases and to kits comprising such particles together with at least one endosome destabilizing agent.
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