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公开(公告)号:US09605066B2
公开(公告)日:2017-03-28
申请号:US14473186
申请日:2014-08-29
申请人: BIOTEST AG
发明人: Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Andrea Wartenberg-Demand , Marcus Gutscher , Judith Wessels-Kranz
IPC分类号: A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/11 , C12N15/13 , C12N15/63 , G01N33/68
CPC分类号: C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要: Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof is capable of being administered to a subject in the absence of an intolerable increase in the level of pro-inflammatory cytokines. Further provided are methods of treatment involving the use of the antibody or fragment thereof.
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公开(公告)号:US09540436B2
公开(公告)日:2017-01-10
申请号:US14591133
申请日:2015-01-07
申请人: Biotest AG
发明人: Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth
CPC分类号: C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要: Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (IL-10), wherein said antibody or fragment thereof: (i) binds to the same region of IL-10 as the IL-10 receptor α (IL-I10Ra) and is not capable of binding IL-10 when the IL-10 is bound to the IL-10 receptor; and (ii) binds to IL-10 in homodimeric form by binding a discontinuous epitope comprising residues of both monomers. Further provided are related products and methods involving the use of the antibody or fragment thereof.
摘要翻译: 提供能够结合白细胞介素-10(IL-10)的人源化或嵌合抗体或其片段,其中所述抗体或其片段:(i)结合与IL-10受体α相同的IL-10区域( IL-10Ra),并且当IL-10与IL-10受体结合时不能结合IL-10; 和(ii)通过结合包含两个单体的残基的不连续表位与同型二聚体形式的IL-10结合。 进一步提供涉及使用抗体或其片段的相关产物和方法。
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