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公开(公告)号：US11623028B2
公开(公告)日：2023-04-11
申请号：US15766842
申请日：2016-06-14
发明人： Deyuan Zhang , Haiping Qi , Wenjiao Lin , Gui Zhang , Li Qin
IPC分类号： A61K9/00 , A61K33/26 , A61L27/04 , A61L31/08 , A61L27/50 , A61L27/58 , A61L31/02 , A61L31/14 , A61L31/10 , A61L31/06 , A61L31/16
摘要： An absorbable implantable medical device made of iron-based alloy, including a base made of iron-based alloy and a complex, wherein the complex includes a complexing agent. In a physiological solution, the base made of iron-based alloy can react with the complexing agent to generate a water-soluble iron complex having solubility in the physiological solution of no less than 10 mg/L. A corrosion product generated after the absorbable implantable medical device made of iron-based alloy is implanted in a human body can be quickly metabolized/absorbed by the body.
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公开(公告)号：US10973948B2
公开(公告)日：2021-04-13
申请号：US16473722
申请日：2017-12-19
发明人： Jun Hu , Deyuan Zhang , Hongtao Sun , Liping Chen
IPC分类号： A61L31/02 , A61L31/06 , A61L31/14 , A61L31/16 , A61L17/00 , A61L17/10 , A61L17/12 , A61L27/04 , A61L27/34 , A61L27/58
摘要： An absorbable iron-based device includes an iron-based matrix and degradable polyester in contact with the surface of the iron-based matrix. The mass fraction of a low-molecular-weight part of the degradable polyester is less than or equal to 5%, and the molecular weight of the low-molecular-weight part is less than 10,000; or the mass fraction of a residual monomer in the degradable polyester is less than or equal to 2%.
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3.发明授权公开(公告)号：US11969368B2
公开(公告)日：2024-04-30
申请号：US17859563
申请日：2022-07-07
发明人： Deyuan Zhang , Xianmiao Chen , Wenjiao Lin , Xiangdong Liu
IPC分类号： A61F2/82 , A61L27/04 , A61L31/02 , C21D8/10 , C21D9/08 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/14 , C22C38/42 , C22C38/44 , C23C8/02 , C23C8/26 , B21C1/00 , B21C1/24
CPC分类号： A61F2/82 , A61L27/04 , A61L31/02 , A61L31/022 , C21D8/105 , C21D9/08 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/14 , C22C38/42 , C22C38/44 , C23C8/02 , C23C8/26 , A61F2240/001 , B21C1/00 , B21C1/003 , B21C1/24
摘要： A lumen stent preform is provided using a plasma nitriding technology, a preparation method thereof, a method for preparing a lumen stent by using the preform, and a lumen stent obtained according to the method. The preform is manufactured by using pure iron or an iron alloy containing no strong nitrogen compound, has a hardness of 160-250HV0.05/10, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. Alternatively, the preform is an iron alloy containing a strong nitrogen compound, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. The lumen stem preform meets the requirements of a conventional stent for radial strength and plasticity, so that plasma nitriding is applicable to commercial preparation of a lumen stent.
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公开(公告)号：US20230142931A1
公开(公告)日：2023-05-11
申请号：US17915430
申请日：2021-04-07
发明人： Deyuan Zhang , Haiping Qi , Wenjiao Lin
CPC分类号： A61L31/022 , C08L67/04 , A61L31/16 , A61L31/10
摘要： The present invention relates to a zinc-containing medical device, including a zinc-containing matrix and a polylactic acid coating arranged on the zinc-containing matrix. The polylactic acid coating has a thickness of x μm; and when x and the weight-average molecular weight Mn (kDa) of polylactic acid satisfied the following formula:
(
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b
+
b
2
-
4
a
c
)
/
2
a
-
2
≤
x
≤
(
-
b
+
b
2
-
4
a
c
)
/
2
a
+
2
,
the corrosion rate of zinc in the matrix is relatively small, sufficient mechanical properties can be maintained within the repair period, and the biological risk is relatively low. When the polylactic acid is poly-racemic lactic acid, a=0.0336 ln(Mn)−0.1449, b=−0.472 ln(Mn)+2.1524, and c=1.1604 ln(Mn)−5.7128; and when the polylactic acid is poly-L-lactic acid, a=−0.006 ln(Mn)+0.03441, b=0.0648 ln(Mn)−0.3662, and c=−0.162 ln(Mn)+0.7847.-
公开(公告)号：US11819591B2
公开(公告)日：2023-11-21
申请号：US15775137
申请日：2016-06-27
发明人： Wenjiao Lin , Deyuan Zhang
CPC分类号： A61L31/148 , A61L17/10 , A61L31/022 , A61L31/06 , A61L31/10 , A61L31/128 , A61L27/042 , A61L31/128 , C08L67/04 , A61L31/128 , C08L73/02 , A61L31/128 , C08L77/04 , A61L31/06 , C08L67/04 , A61L31/06 , C08L73/02 , A61L31/06 , C08L77/04 , A61L31/10 , C08L77/04 , A61L31/10 , C08L73/02 , A61L31/10 , C08L67/04
摘要： An iron-based alloy absorbable and implantable medical device for internal fixation. A substrate includes an iron-based alloy and degradable polymer. The mass ratio of the iron-based alloy to the degradable polymer is between 1:4 and 4:1. The weight-average molecular weight of the degradable polymer is between 150000 to 3000000, and the polydispersity index thereof is between 1 and 6. The device further includes antioxidants. The iron-based alloy is used as a load-bearing framework or reinforcement phase of the device. By adjusting the mass ratio of the iron-based alloy to the degradable polymer and the combination mode thereof, the corrosion rate of the iron-based alloy in the late period of the implantation is accelerated, and the quantity of corrosion products poorly soluble in the iron-based alloy is reduced. Adding antioxidants to the device further reduces the quantity of the corrosion products poorly soluble in the iron-based alloy.
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公开(公告)号：US20240042108A1
公开(公告)日：2024-02-08
申请号：US18267708
申请日：2021-12-28
发明人： Deyuan Zhang , Haiping Qi
CPC分类号： A61L31/124 , A61L31/022 , A61L31/148
摘要： The present invention relates to the technical field of medical devices, and in particular to an orthopedic internal fixation implant medical device, including an iron matrix and a filling material including polylactic acid and an alkaline substance. The polylactic acid has a weight-average molecular weight of Mw kDa, the alkaline substance includes a metal element, the mass ratio of the metal element in the alkaline substance to the polylactic acid is p, and the p and the Mw satisfy a formula of 2Mw{circumflex over ( )}−0.8≤p≤30Mw{circumflex over ( )}−0.5. The orthopedic internal fixation implant medical device, with good mechanical properties, can control local pH values and induce bone healing.
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公开(公告)号：US11684692B2
公开(公告)日：2023-06-27
申请号：US16473896
申请日：2017-12-19
发明人： Hongtao Sun , Deyuan Zhang , Jun Hu , Liping Chen
IPC分类号： A61L27/04 , A61L27/34 , A61L27/54 , A61L27/58 , A61L17/10 , A61L17/00 , A61L31/02 , A61L31/06 , A61L31/14 , A61L31/16 , C08L67/04 , A61K45/06
CPC分类号： A61L27/04 , A61L17/005 , A61L17/105 , A61L27/34 , A61L27/54 , A61L27/58 , A61L31/022 , A61L31/06 , A61L31/148 , A61L31/16 , C08L67/04 , A61K45/06 , A61L2300/41 , A61L2300/416 , A61L2300/42
摘要： An absorbable iron-based instrument is provided having an iron-based substrate, a zinc-containing protector in contact with the iron-based substrate, and a degradable polyester in contact with the iron-based substrate and/or the zinc-containing protector. The range of the ratio of the mass of the zinc-containing protector to the mass of the iron-based substrate is 1:200 to 1:2. In the degradable polyester, the mass fraction of a low-molecular-weight part with a molecular weight of less than 10,000 is less than or equal to 5%; alternatively, in the degradable polyester, the mass fraction of a residual monomer is less than or equal to 2%.
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8.发明公开公开(公告)号：US20240261119A1
公开(公告)日：2024-08-08
申请号：US18638543
申请日：2024-04-17
发明人： Deyuan Zhang , Xianmiao Chen , Xiangdong Liu
IPC分类号： A61F2/82 , A61L27/04 , A61L31/02 , B21C1/00 , B21C1/24 , C21D8/10 , C21D9/08 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/14 , C22C38/42 , C22C38/44 , C23C8/02 , C23C8/26
CPC分类号： A61F2/82 , A61L27/04 , A61L31/02 , A61L31/022 , C21D8/105 , C21D9/08 , C22C38/002 , C22C38/02 , C22C38/04 , C22C38/14 , C22C38/42 , C22C38/44 , C23C8/02 , C23C8/26 , A61F2240/001 , B21C1/00 , B21C1/003 , B21C1/24
摘要： A lumen stent preform is provided using a plasma nitriding technology, a preparation method thereof, a method for preparing a lumen stent by using the preform, and a lumen stent obtained according to the method. The preform is manufactured by using pure iron or an iron alloy containing no strong nitrogen compound, has a hardness of 160-250 HV0.05/10, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. Alternatively, the preform is an iron alloy containing a strong nitrogen compound, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. The lumen stent preform meets the requirements of a conventional stent for radial strength and plasticity, so that plasma nitriding is applicable to commercial preparation of a lumen stent.
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9.发明申请公开(公告)号：US20220339012A1
公开(公告)日：2022-10-27
申请号：US17859563
申请日：2022-07-07
发明人： Deyuan Zhang , Xianmiao Chen , Wenjiao Lin , Xiangdong Liu
IPC分类号： A61F2/82 , A61L27/04 , A61L31/02 , C21D8/10 , C21D9/08 , C22C38/00 , C22C38/02 , C22C38/04 , C22C38/14 , C22C38/42 , C22C38/44 , C23C8/02 , C23C8/26
摘要： A lumen stent preform is provided using a plasma nitriding technology, a preparation method thereof, a method for preparing a lumen stent by using the preform, and a lumen stent obtained according to the method. The preform is manufactured by using pure iron or an iron alloy containing no strong nitrogen compound, has a hardness of 160-250HV0.05/10, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. Alternatively, the preform is an iron alloy containing a strong nitrogen compound, and has a microstructure that is a deformed structure having a grain size scale greater than or equal to 9 or a deformed structure after cold machining. The lumen stem preform meets the requirements of a conventional stent for radial strength and plasticity, so that plasma nitriding is applicable to commercial preparation of a lumen stent.
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公开(公告)号：US10946121B2
公开(公告)日：2021-03-16
申请号：US16063798
申请日：2016-06-27
发明人： Ziqiang Liu , Haiping Qi , Wenjiao Lin , Deyuan Zhang
摘要： An absorbable iron-based alloy implantable medical device, including an iron-based alloy substrate and a degradable polymer coating and a zinc-containing protector which are arranged on the surface of the iron-based alloy substrate. The zinc-containing protector is selected from zinc and/or a zinc alloy, or a mixture of zinc and/or a zinc alloy and a degradable binder. The weight percentage of the zinc and/or zinc alloy in the mixture is greater than or equal to 20% and less than 100%. The zinc-containing protector is capable of delaying the corrosion of the iron-based alloy substrate during the early stage of implantation, such that the iron-based alloy substrate essentially avoids corrosion during the early stage of implantation and the clinical mechanical property requirements for the device in the early stage of implantation can be satisfied.
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