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公开(公告)号：US11623028B2
公开(公告)日：2023-04-11
申请号：US15766842
申请日：2016-06-14
发明人： Deyuan Zhang , Haiping Qi , Wenjiao Lin , Gui Zhang , Li Qin
IPC分类号： A61K9/00 , A61K33/26 , A61L27/04 , A61L31/08 , A61L27/50 , A61L27/58 , A61L31/02 , A61L31/14 , A61L31/10 , A61L31/06 , A61L31/16
摘要： An absorbable implantable medical device made of iron-based alloy, including a base made of iron-based alloy and a complex, wherein the complex includes a complexing agent. In a physiological solution, the base made of iron-based alloy can react with the complexing agent to generate a water-soluble iron complex having solubility in the physiological solution of no less than 10 mg/L. A corrosion product generated after the absorbable implantable medical device made of iron-based alloy is implanted in a human body can be quickly metabolized/absorbed by the body.
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公开(公告)号：US20230142931A1
公开(公告)日：2023-05-11
申请号：US17915430
申请日：2021-04-07
发明人： Deyuan Zhang , Haiping Qi , Wenjiao Lin
CPC分类号： A61L31/022 , C08L67/04 , A61L31/16 , A61L31/10
摘要： The present invention relates to a zinc-containing medical device, including a zinc-containing matrix and a polylactic acid coating arranged on the zinc-containing matrix. The polylactic acid coating has a thickness of x μm; and when x and the weight-average molecular weight Mn (kDa) of polylactic acid satisfied the following formula:
(
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b
+
b
2
-
4
a
c
)
/
2
a
-
2
≤
x
≤
(
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b
+
b
2
-
4
a
c
)
/
2
a
+
2
,
the corrosion rate of zinc in the matrix is relatively small, sufficient mechanical properties can be maintained within the repair period, and the biological risk is relatively low. When the polylactic acid is poly-racemic lactic acid, a=0.0336 ln(Mn)−0.1449, b=−0.472 ln(Mn)+2.1524, and c=1.1604 ln(Mn)−5.7128; and when the polylactic acid is poly-L-lactic acid, a=−0.006 ln(Mn)+0.03441, b=0.0648 ln(Mn)−0.3662, and c=−0.162 ln(Mn)+0.7847.-
公开(公告)号：US20240042108A1
公开(公告)日：2024-02-08
申请号：US18267708
申请日：2021-12-28
发明人： Deyuan Zhang , Haiping Qi
CPC分类号： A61L31/124 , A61L31/022 , A61L31/148
摘要： The present invention relates to the technical field of medical devices, and in particular to an orthopedic internal fixation implant medical device, including an iron matrix and a filling material including polylactic acid and an alkaline substance. The polylactic acid has a weight-average molecular weight of Mw kDa, the alkaline substance includes a metal element, the mass ratio of the metal element in the alkaline substance to the polylactic acid is p, and the p and the Mw satisfy a formula of 2Mw{circumflex over ( )}−0.8≤p≤30Mw{circumflex over ( )}−0.5. The orthopedic internal fixation implant medical device, with good mechanical properties, can control local pH values and induce bone healing.
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公开(公告)号：US20200215237A1
公开(公告)日：2020-07-09
申请号：US16063798
申请日：2016-06-27
发明人： Ziqiang LIU , Haiping Qi , Wenjiao LIN , Deyuan ZHANG
摘要： An absorbable iron-based alloy implantable medical device, including an iron-based alloy substrate and a degradable polymer coating and a zinc-containing protector which are arranged on the surface of the iron-based alloy substrate. The zinc-containing protector is selected from zinc and/or a zinc alloy, or a mixture of zinc and/or a zinc alloy and a degradable binder. The weight percentage of the zinc and/or zinc alloy in the mixture is greater than or equal to 20% and less than 100%. The zinc-containing protector is capable of delaying the corrosion of the iron-based alloy substrate during the early stage of implantation, such that the iron-based alloy substrate essentially avoids corrosion during the early stage of implantation and the clinical mechanical property requirements for the device in the early stage of implantation can be satisfied.
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公开(公告)号：US10946121B2
公开(公告)日：2021-03-16
申请号：US16063798
申请日：2016-06-27
发明人： Ziqiang Liu , Haiping Qi , Wenjiao Lin , Deyuan Zhang
摘要： An absorbable iron-based alloy implantable medical device, including an iron-based alloy substrate and a degradable polymer coating and a zinc-containing protector which are arranged on the surface of the iron-based alloy substrate. The zinc-containing protector is selected from zinc and/or a zinc alloy, or a mixture of zinc and/or a zinc alloy and a degradable binder. The weight percentage of the zinc and/or zinc alloy in the mixture is greater than or equal to 20% and less than 100%. The zinc-containing protector is capable of delaying the corrosion of the iron-based alloy substrate during the early stage of implantation, such that the iron-based alloy substrate essentially avoids corrosion during the early stage of implantation and the clinical mechanical property requirements for the device in the early stage of implantation can be satisfied.
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