公开(公告)号：US20200283474A1

公开(公告)日：2020-09-10

申请号：US16793676

申请日：2020-02-18

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Glen BOLTON ,  Keith SELVITELLI

IPC: C07K1/22 ,  A61L2/00 ,  C07K16/06 ,  C07K1/16 ,  C07K14/755

Abstract: The present invention is directed to a method of inactivating virus that is present during production of a polypeptide of interest. In particular, the present invention is directed to a method of on-column virus inactivation using a low pH and high salt wash solution that effectively inactivates viruses with minimum recovery loss of the polypeptide.

公开(公告)号：US20250136640A1

公开(公告)日：2025-05-01

申请号：US18903305

申请日：2024-10-01

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Glen BOLTON ,  Keith SELVITELLI

IPC: C07K1/22 ,  A61L2/00 ,  C07K1/16 ,  C07K14/755 ,  C07K16/06

Abstract: The present invention is directed to a method of inactivating virus that is present during production of a polypeptide of interest. In particular, the present invention is directed to a method of on-column virus inactivation using a low pH and high salt wash solution that effectively inactivates viruses with minimum recovery loss of the polypeptide.

公开(公告)号：US20230331774A1

公开(公告)日：2023-10-19

申请号：US18153669

申请日：2023-01-12

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Glen BOLTON ,  Keith SELVITELLI

IPC: C07K1/22 ,  A61L2/00 ,  C07K16/06 ,  C07K1/16 ,  C07K14/755

CPC classification number: C07K1/22 ,  A61L2/0088 ,  C07K16/065 ,  C07K1/165 ,  C07K14/755 ,  A61L2202/21 ,  C07K2319/30

Abstract: The present invention is directed to a method of inactivating virus that is present during production of a polypeptide of interest. In particular, the present invention is directed to a method of on-column virus inactivation using a low pH and high salt wash solution that effectively inactivates viruses with minimum recovery loss of the polypeptide.