公开(公告)号：US20230023927A1

公开(公告)日：2023-01-26

申请号：US17830745

申请日：2022-06-02

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Robert T. PETERS ,  Adam R. MEZO ,  Daniel S. RIVERA ,  Alan J. BITONTI ,  Susan C. LOW

IPC: C07K14/755 ,  C07K14/555 ,  A61K47/64 ,  A61K47/68 ,  C07K14/59 ,  C07K14/475 ,  C07K16/00 ,  C12N9/64 ,  C07K14/565 ,  A61K47/60 ,  C07K14/505 ,  C07K14/705 ,  C07K14/745 ,  C12N9/96 ,  C07K14/61 ,  C07K14/56 ,  A61K38/00

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US20220010000A1

公开(公告)日：2022-01-13

申请号：US17480984

申请日：2021-09-21

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Robert T. PETERS ,  Adam R. MEZO ,  Daniel S. RIVERA ,  Alan J. BITONTI ,  Susan C. LOW

IPC: C07K14/755 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  A61K47/68 ,  C07K14/565 ,  C12N9/96 ,  A61K47/60 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US20170267744A1

公开(公告)日：2017-09-21

申请号：US15439481

申请日：2017-02-22

Applicant: Bioverativ Therapeutics Inc.

Inventor： Susan C. LOW ,  Robert T. PETERS

IPC: C07K14/755 ,  C12N9/60 ,  C12P21/06 ,  C12N9/64

CPC classification number: C07K14/755 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/43 ,  C12N9/60 ,  C12N9/6424 ,  C12P21/06

Abstract: The present invention provides methods of reducing nonprocessed Factor VIII or a chimeric polypeptide comprising Factor VIII comprising co-transfecting in a host cell a polynucleotide encoding Factor VIII with a polynucleotide encoding a protein convertase, where the endogenous processing enzymes of the host cell are insufficient to convert all of the Factor VIII to its processed isoform; expressing a proprotein convertase from a second polynucleotide in the host cell; and reducing the nonprocessed Factor VIII by processing with said proprotein convertase.