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公开(公告)号：US20220265780A1
公开(公告)日：2022-08-25
申请号：US17587941
申请日：2022-01-28
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Jennifer A. DUMONT , Susan LOW , Alan J. BITONTI , Glenn PIERCE , Alvin LUK , Haiyan JIANG , Byron MCKINNEY , Matt OTTMER , Jurg SOMMER , Karen NUGENT , Lian LI , Robert PETERS
IPC: A61K38/37 , A61K47/64 , A61K47/68 , C07K14/755 , C07K16/46
Abstract: The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US20220010000A1
公开(公告)日：2022-01-13
申请号：US17480984
申请日：2021-09-21
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Robert T. PETERS , Adam R. MEZO , Daniel S. RIVERA , Alan J. BITONTI , Susan C. LOW
IPC: C07K14/755 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/56 , C07K14/745 , C07K16/00 , C12N9/64 , A61K47/68 , C07K14/565 , C12N9/96 , A61K47/60 , C07K14/59 , C07K14/61 , C07K14/705 , A61K47/64
Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
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Patent Agency Ranking
公开(公告)号：US20210348150A1
公开(公告)日：2021-11-11
申请号：US17239208
申请日：2021-04-23
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Daniel S. RIVERA , Robert T. PETERS , Alan J. BITONTI
Abstract: The invention relates to a chimeric protein comprising at least one clotting factor and at least a portion of an immunoglobulin constant region. The invention relates to a method of treating a hemostatic disorder comprising administering a therapeutically effective amount of a chimeric protein wherein the chimeric protein comprises at least one clotting factor and at least a portion of an immunoglobulin constant region.
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公开(公告)号：US20190262429A1
公开(公告)日：2019-08-29
申请号：US16270302
申请日：2019-02-07
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Jennifer A. DUMONT , Susan LOW , Alan J. BITONTI , Glenn PIERCE , Alvin LUK , Haiyan JIANG , Byron MCKINNEY , Matt OTTMER , Jurg SOMMER , Karen NUGENT , Lian LI , Robert PETERS
IPC: A61K38/37 , A61K47/64 , C07K14/755 , A61K47/68 , C07K16/46
Abstract: The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII: polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US20230023927A1
公开(公告)日：2023-01-26
申请号：US17830745
申请日：2022-06-02
Applicant: BIOVERATIV THERAPEUTICS INC.
Inventor： Robert T. PETERS , Adam R. MEZO , Daniel S. RIVERA , Alan J. BITONTI , Susan C. LOW
IPC: C07K14/755 , C07K14/555 , A61K47/64 , A61K47/68 , C07K14/59 , C07K14/475 , C07K16/00 , C12N9/64 , C07K14/565 , A61K47/60 , C07K14/505 , C07K14/705 , C07K14/745 , C12N9/96 , C07K14/61 , C07K14/56 , A61K38/00
Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.
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公开(公告)号：US20210220476A1
公开(公告)日：2021-07-22
申请号：US17112280
申请日：2020-12-04
Applicant: Bioverativ Therapeutics Inc.
Inventor： Jennifer A. DUMONT , Susan LOW , Alan J. BITONTI , Glenn PIERCE , Alvin LUK , Haiyan JIANG , Byron MCKINNEY , Matt OTTMER , Jurg SOMMER , Karen NUGENT , Lian LI , Robert T. PETERS
IPC: A61K47/68 , A61K47/60 , A61K38/37 , C07K14/755 , G01N33/86
Abstract: The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US20180360982A1
公开(公告)日：2018-12-20
申请号：US15991629
申请日：2018-05-29
Applicant: Bioverativ Therapeutics Inc.
Inventor： Jennifer A. DUMONT , Susan LOW , Alan J. BITONTI , Glenn PIERCE , Alvin LUK , Haiyan JIANG , Byron MCKINNEY , Matt OTTMER , Jurg SOMMER , Karen NUGENT , Lian LI , Robert T. PETERS
IPC: A61K47/68 , A61K47/60 , G01N33/86 , A61K38/37 , C07K14/755
Abstract: The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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