公开(公告)号：US20180194725A1

公开(公告)日：2018-07-12

申请号：US15743427

申请日：2016-07-15

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Kenneth Bayles ,  Rongshi Li ,  Yan Liu

IPC: C07D207/34 ,  C07D207/333 ,  C07D231/16 ,  C07D233/90 ,  C07D233/68 ,  C07D249/12 ,  A61P31/04 ,  A61P35/00

CPC classification number: C07D207/34 ,  A61P31/04 ,  A61P35/00 ,  C07D207/333 ,  C07D231/16 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/12

Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.

公开(公告)号：US20190330147A1

公开(公告)日：2019-10-31

申请号：US16505843

申请日：2019-07-09

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Kenneth Bayles ,  Rongshi Li ,  Yan Liu

IPC: C07D207/34 ,  A61P35/00 ,  A61P31/04 ,  C07D207/333 ,  C07D231/16 ,  C07D233/90 ,  C07D233/68 ,  C07D233/64 ,  C07D249/12

Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.

公开(公告)号：US20220339279A1

公开(公告)日：2022-10-27

申请号：US17721709

申请日：2022-04-15

Applicant: Board of Regents of the University of Nebraska

Inventor： Kenneth Bayles ,  Gloria Borgstahl ,  Siddappa Byrareddy ,  Chittibabu Guda ,  St. Patrick Reid ,  Mara Jana Broadhurst ,  Andrew Schnaubelt

IPC: A61K39/215 ,  C07K14/165 ,  A61P31/14 ,  G01N33/569

Abstract: Disclosed are recombinant proteins, compositions, vectors, kits, data analyses, and methods for inducing an immune response against, or detecting exposure to, SARS-CoV-2. In particular, the compositions, vectors, kits, data analyses and methods may be utilized to immunize subjects against disease associated with SARS-CoV-2 infection or to protect subjects from SARS-CoV-2 infection. In some embodiments, the recombinant proteins are useful in the production of antibodies against SARS-CoV-2, and for the detection of exposure to SARS-CoV-2.

公开(公告)号：US10414725B2

公开(公告)日：2019-09-17

申请号：US15743427

申请日：2016-07-15

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Kenneth Bayles ,  Rongshi Li ,  Yan Liu

IPC: C07D207/34 ,  C07D231/16 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/12 ,  C07D207/333 ,  A61P31/04 ,  A61P35/00

Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.

公开(公告)号：US10954192B2

公开(公告)日：2021-03-23

申请号：US16505843

申请日：2019-07-09

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Kenneth Bayles ,  Rongshi Li ,  Yan Liu

IPC: C07D207/34 ,  C07D231/16 ,  C07D233/68 ,  C07D233/90 ,  C07D249/12 ,  C07D207/333 ,  C07D233/64 ,  A61P31/04 ,  A61P35/00

Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.