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公开(公告)号：US20210220828A1
公开(公告)日：2021-07-22
申请号：US16631984
申请日：2019-01-15
发明人： Haochen CUI , Wenliang YAO , Peizhi CAI , Chuncheng CHE , Yingying ZHAO , Yuelei XIAO , Le GU , Yue GENG , Nan ZHAO , Hui LIAO , Fengchun PANG
IPC分类号： B01L3/00
摘要： A biological detection substrate, a microfluidic chip and a driving method thereof, and a microfluidic detection component are provided. The biological detection substrate includes a sample capture region, the sample capture region includes an electromagnetic coil, and the electromagnetic coil is configured to capture a sample in a sample droplet that is driven to pass through the sample capture region.
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公开(公告)号：US20210197163A1
公开(公告)日：2021-07-01
申请号：US16071932
申请日：2018-01-02
发明人： Yue GENG , Fengchun PANG , Peizhi CAI , Le GU
IPC分类号： B01J19/00 , C12Q1/6874
摘要： A gene sequencing chip is provided, which includes: an upper substrate including a plurality of liquid inlets for inletting liquid drops; a lower substrate opposite to the upper substrate and spaced therefrom by a gap, the gap being provided for allowing the liquid drops to move therein, the lower substrate including a liquid drop operation region, the liquid drop operation region including a manipulation electrode array. The manipulation electrode array includes multiple first sub-arrays for preparing a gene library, multiple second sub-arrays for sequencing the gene library which is prepared, each first sub-array being adjacent to one of the multiple second sub-arrays. Based on the gene sequencing chip provided in this disclosure, operations to tiny liquid drops such as movement, fusion and splitting can be accurately manipulated by using digital microfluidic techniques, and all steps of the gene sequencing from library preparation to gene sequencing can be completed on one chip.
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公开(公告)号：US20210060555A1
公开(公告)日：2021-03-04
申请号：US16632931
申请日：2019-01-02
发明人： Wenliang YAO , Haochen CUI , Peizhi CAI , Yuelei XIAO , Fengchun PANG , Yue GENG , Le GU , Nan ZHAO , Hui LIAO , Yingying ZHAO , Chuncheng CHE
IPC分类号： B01L3/00
摘要： A microfluidic device, a microfluidic detection assembly and a detection method for the microfluidic device. The microfluidic device includes a first substrate and a second substrate; the first substrate and the second substrate are oppositely arranged to define a channel between the first substrate and the second substrate, the channel is configured for liquid to flow, the first substrate includes a base substrate and a plurality of control assemblies which are arranged on the base substrate along an extending direction of the channel, each of the plurality of control assemblies includes: a first electrode, a second electrode and a plurality of coils, and the first electrode is configured to input currents into the plurality of coils, and the plurality of coils are connected in parallel to the second electrode.
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公开(公告)号：US20190187057A1
公开(公告)日：2019-06-20
申请号：US16323007
申请日：2018-05-11
发明人： Yue GENG , Peizhi CAI , Fengchun PANG , Le GU
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , A61B5/0071 , G01N21/6428 , G01N33/54366 , G01N2021/0106
摘要： A biosensor, and a preparation and biosensing method therefor. The biosensor includes: a sensing substrate, wherein a plurality of sensing suspending arms arranged in an array are arranged on the sensing substrate, and the sensing suspending arms have identification markers; and a detection substrate, the detection substrate including a plurality of light detection assemblies arranged in an array, wherein the light detection assemblies and the sensing suspending arms are arranged in one-to-one correspondence, each of the light detection assemblies includes a photodiode and a thin film transistor, and the photodiode is connected to the thin film transistor.
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5.发明申请公开(公告)号：US20210346891A1
公开(公告)日：2021-11-11
申请号：US16314679
申请日：2018-06-08
发明人： Yue GENG , Peizhi CAI , Fengchun PANG , Le GU , Chuncheng CHE , Hailin XUE , Xibin SHAO
IPC分类号： B01L3/00
摘要： A microfluidic chip and controlling method are provided. The microfluidic chip includes a microfluidic substrate, comprising a first substrate, a droplet driving assembly over the first substrate, and a temperature detection assembly. The droplet driving assembly includes a first electrode layer having a plurality of control electrodes, and each of the plurality of control electrodes is configured as part of a driving unit to drive a droplet to move along a predetermined path over the microfluidic substrate. The temperature detection assembly comprises at least one temperature sensor. The at least one temperature sensor positionally corresponds to the plurality of control electrodes such that each of the at least one temperature sensor detects a temperature at a position associated with one of the plurality of control electrodes corresponding to the each of the at least one temperature sensor.
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公开(公告)号：US20190204262A1
公开(公告)日：2019-07-04
申请号：US16235455
申请日：2018-12-28
发明人： Fengchun PANG , Peizhi CAI , Yue GENG , Le GU , Chuncheng CHE
IPC分类号： G01N27/403 , G01N27/27
CPC分类号： G01N27/403 , G01N27/27
摘要： An electrochemical detection chip includes a first substrate and a second substrate opposite to each other, a plurality of driving electrodes, first detection electrodes and second detection electrodes. The plurality of driving electrodes are arranged on a side of the first substrate facing toward the second substrate and are arranged independently. The first detection electrodes and the second detection electrodes are arranged at a plurality of positions on a side of the second substrate facing toward the first substrate that are directly opposite at least a part of the plurality of driving electrodes, and are spaced apart from each other.
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公开(公告)号：US20180237846A1
公开(公告)日：2018-08-23
申请号：US15715284
申请日：2017-09-26
发明人： Yue GENG , Peizhi CAI , Fengchun PANG
CPC分类号： C12Q1/6869 , B01L3/502761 , B01L3/5085 , B01L2200/0668 , B01L2300/0627 , B01L2300/0663 , B01L2300/0829 , B01L2400/043 , C12Q2527/101 , C12Q2535/122
摘要： Provided is a gene sequencing substrate and its gene sequencing method, and a gene sequencing device. The gene sequencing substrate includes a base substrate; and at least one sequencing unit, disposed on the base substrate, wherein the sequencing unit includes: a reaction cell, configured to accommodate a target sample; and at least one temperature sensor disposed corresponding to the reaction cell and configured to sense a temperature of the reaction cell.
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公开(公告)号：US20220184577A1
公开(公告)日：2022-06-16
申请号：US17683059
申请日：2022-02-28
发明人： Yue GENG , Fengchun PANG , Peizhi CAI , Le GU
IPC分类号： B01J19/00 , C12Q1/6874
摘要： A gene sequencing chip is provided, which includes: an upper substrate including a plurality of liquid inlets for inletting liquid drops; a lower substrate opposite to the upper substrate and spaced therefrom by a gap, the gap being provided for allowing the liquid drops to move therein, the lower substrate including a liquid drop operation region, the liquid drop operation region including a manipulation electrode array. The manipulation electrode array includes multiple first manipulation electrode array for preparing a gene library, multiple second manipulation electrode array for sequencing the gene library which is prepared, each first sub-array being adjacent to one of the multiple second manipulation electrode array. Based on the gene sequencing chip provided in this disclosure, operations to tiny liquid drops such as movement, fusion and splitting can be accurately manipulated by using digital microfluidic techniques, and all steps of the gene sequencing from library preparation to gene sequencing can be completed on one chip.
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公开(公告)号：US20210164032A1
公开(公告)日：2021-06-03
申请号：US16072923
申请日：2017-12-15
发明人： Fengchun PANG , Peizhi CAI , Yue GENG
IPC分类号： C12Q1/6869 , C12Q1/6837
摘要： A chip, a detection system and a gene sequencing method are provided. When the chip is used for gene sequencing, sample genes and reversible terminating nucleotides are added into micropores and matched therein to release hydrogen ions such that a Nernst potential is induced on an ion-sensitive film surface, and a voltage is applied to the transparent electrode layer to generate an electric field, thereby controlling the switching layer to change its state, and then a base type of the genes is determined based on a type of reversible terminating nucleotide corresponding to information of light emitted from the switching layer upon changes in the state of the switching layer, thereby gene sequencing is achieved.
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公开(公告)号：US20210063340A1
公开(公告)日：2021-03-04
申请号：US16632661
申请日：2019-01-02
发明人： Wenliang YAO , Haochen CUI , Peizhi CAI , Fengchun PANG , Yue GENG , Le GU , Nan ZHAO , Yuelei XIAO , Hui LIAO , Yingying ZHAO , Chuncheng CHE
IPC分类号： G01N27/327 , B01L3/00 , H01H29/28
摘要： A chip, a method of operating a chip, and a detection device are provided. The chip includes a detection cavity and a working electrode, the detection cavity is configured to be capable of containing a plurality of droplets, and the working electrode is arranged in the detection cavity and is configured to regularly arrange the plurality of droplets in the detection cavity along an extending direction of the working electrode.
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