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公开(公告)号：US20200338549A1
公开(公告)日：2020-10-29
申请号：US16768558
申请日：2019-11-13
发明人： Yingying ZHAO , Peizhi CAI , Le GU , Fengchun PANG , Yue GENG , Yuelei XIAO , Haochen CUI , Nan ZHAO , Hui LIAO , Wenliang YAO , Chuncheng CHE
IPC分类号： B01L3/00
摘要： The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.
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公开(公告)号：US20210063340A1
公开(公告)日：2021-03-04
申请号：US16632661
申请日：2019-01-02
发明人： Wenliang YAO , Haochen CUI , Peizhi CAI , Fengchun PANG , Yue GENG , Le GU , Nan ZHAO , Yuelei XIAO , Hui LIAO , Yingying ZHAO , Chuncheng CHE
IPC分类号： G01N27/327 , B01L3/00 , H01H29/28
摘要： A chip, a method of operating a chip, and a detection device are provided. The chip includes a detection cavity and a working electrode, the detection cavity is configured to be capable of containing a plurality of droplets, and the working electrode is arranged in the detection cavity and is configured to regularly arrange the plurality of droplets in the detection cavity along an extending direction of the working electrode.
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公开(公告)号：US20210229092A1
公开(公告)日：2021-07-29
申请号：US16644904
申请日：2019-03-11
发明人： Haochen CUI , Jian LI , Yingying ZHAO , Wenliang YAO , Peizhi CAI , Yue GENG , Le GU , Fengchun PANG , Yuelei XIAO , Hui LIAO , Nan ZHAO
IPC分类号： B01L3/00 , H01J31/26 , G01N33/535 , G01N21/76
摘要： A microfluidic chip and a detection method using the microfluidic chip. The microfluidic chip includes: at least one micro-chamber; a photocathode located on a side of the at least one micro-chamber and configured to receive photons emitted from the micro-chamber to generate electrons; a micro-channel plate located on a side of the photocathode away from the micro-chamber and configured to multiply the electrons generated by the photocathode; and a first electrode located on a side of the micro-channel plate away from the photocathode; the micro-channel plate includes a plurality of micro-channels extending substantially in a thickness direction of the micro-channel plate, a secondary electron emission layer is provided on an inner wall of each of the plurality of micro-channels, and the first electrode is configured to detect the electrons that are multiplied by the micro-channel plate.
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公开(公告)号：US20210162409A1
公开(公告)日：2021-06-03
申请号：US16757902
申请日：2019-03-27
发明人： Wenliang YAO , Nan ZHAO , Peizhi CAI , Fengchun PANG , Yue GENG , Le GU , Yuelei XIAO , Hui LIAO , Yingying ZHAO , Bolin FAN
IPC分类号： B01L3/00 , G01N33/487
摘要： A biological detection chip, a biological detection device, and a detection method thereof are disclosed. The biological detection chip includes a first base substrate and a plurality of detection units arranged in an array along a row direction and a column direction on the first base substrate. Each of the plurality of detection units includes a thin film transistor and an electrode, the thin film transistor is on the first base substrate and includes a gate electrode, a source electrode, and a drain electrode, and the electrode is on a side of the thin film transistor away from the first base substrate and is connected to the drain electrode, and the electrode is configured to carry a biological material to be detected.
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公开(公告)号：US20210060556A1
公开(公告)日：2021-03-04
申请号：US16632934
申请日：2019-01-09
发明人： Wenliang YAO , Nan ZHAO , Haochen CUI , Peizhi CAI , Fengchun PANG , Yue GENG , Le GU , Yuelei XIAO , Hui LIAO , Yingying ZHAO , Chuncheng CHE
摘要： A chip for polymerase chain reaction, a method of operating a chip for polymerase chain reaction, and a reaction device are provided. The chip includes: a sample adding region, a mixing region, a temperature cycling region in a sequential arrangement, and at least one driving unit group. The at least one driving unit group includes a plurality of driving units and is configured to drive a liquid drop to move and sequentially pass through the sample adding region, the mixing region, and the temperature cycling region.
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公开(公告)号：US20210220828A1
公开(公告)日：2021-07-22
申请号：US16631984
申请日：2019-01-15
发明人： Haochen CUI , Wenliang YAO , Peizhi CAI , Chuncheng CHE , Yingying ZHAO , Yuelei XIAO , Le GU , Yue GENG , Nan ZHAO , Hui LIAO , Fengchun PANG
IPC分类号： B01L3/00
摘要： A biological detection substrate, a microfluidic chip and a driving method thereof, and a microfluidic detection component are provided. The biological detection substrate includes a sample capture region, the sample capture region includes an electromagnetic coil, and the electromagnetic coil is configured to capture a sample in a sample droplet that is driven to pass through the sample capture region.
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公开(公告)号：US20210060555A1
公开(公告)日：2021-03-04
申请号：US16632931
申请日：2019-01-02
发明人： Wenliang YAO , Haochen CUI , Peizhi CAI , Yuelei XIAO , Fengchun PANG , Yue GENG , Le GU , Nan ZHAO , Hui LIAO , Yingying ZHAO , Chuncheng CHE
IPC分类号： B01L3/00
摘要： A microfluidic device, a microfluidic detection assembly and a detection method for the microfluidic device. The microfluidic device includes a first substrate and a second substrate; the first substrate and the second substrate are oppositely arranged to define a channel between the first substrate and the second substrate, the channel is configured for liquid to flow, the first substrate includes a base substrate and a plurality of control assemblies which are arranged on the base substrate along an extending direction of the channel, each of the plurality of control assemblies includes: a first electrode, a second electrode and a plurality of coils, and the first electrode is configured to input currents into the plurality of coils, and the plurality of coils are connected in parallel to the second electrode.
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8.发明申请公开(公告)号：US20220193669A1
公开(公告)日：2022-06-23
申请号：US17600090
申请日：2021-02-26
发明人： Yongjia GAO , Yingying ZHAO , Hui LIAO , Wenliang YAO , Le GU , Bolin FAN , Yue LI
摘要： Provided are a temperature control system, a detection system and a temperature control method for a micro-fluidic chip. The temperature control system includes a circuit structure in a functional layer of the micro-fluidic chip, corresponding to a reaction zone of the micro-fluidic chip, and including at least two thermistors and an input port and an output port, wherein the input port and the output port are electrically coupled through the thermistors to form an application circuit; and a controller electrically coupled to each port and configured to select a first input port and a first output port, such that the circuit structure is configured to form a first application circuit as a heating device, and to select a second input port and a second output port, such that the circuit structure is configured to form a second application circuit as a temperature sensor.
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9.发明申请公开(公告)号：US20220314216A1
公开(公告)日：2022-10-06
申请号：US17419846
申请日：2020-09-29
发明人： Bolin FAN , Yingying ZHAO , Le GU , Wenliang YAO , Hui LIAO , Yongjia GAO , Qiuxu WEI
摘要： A micro-fluidic chip is provided. The micro-fluidic chip includes: a first base substrate; a first electrode on the first base substrate and electrically coupled to a wire at a driving end; a second electrode on a side of the first electrode away from the first base substrate and spaced apart and electrically insulated from the first electrode, the second electrode including a plurality of sub-blocks of the second electrode, and an orthographic projection of the second electrode on the first base substrate being at least partially overlapped with an orthographic projection of the first electrode on the first base substrate; and voltage-dividing resistors coupled to the plurality of sub-blocks of the second electrode in one-to-one correspondence and electrically coupled to a ground wire.
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公开(公告)号：US20210129139A1
公开(公告)日：2021-05-06
申请号：US16639867
申请日：2019-01-03
发明人： Yue GENG , Yuelei XIAO , Hui LIAO , Peizhi CAI , Jian LI , Shenkang WU
摘要： A patterning method of a film is disclosed. The method including: providing a film including a first surface; forming n etching barrier layers on the first surface of the film, and n is an integer larger than or equal to 2; and performing n etching processes on the film to form a recessed structure on the first surface using the n etching barrier layers as masks, the recessed structure includes n bottom surfaces respectively having different depths. Two adjacent etching processes of the n etching processes include a previous etching process and a subsequent etching process, and after the previous etching process is completed, a part of the n etching barrier layers is removed to form a mask for the subsequent etching process; a material of the part of the n etching barrier layers which is removed is different from a material of the mask of the subsequent etching process.
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