公开(公告)号：US20160106869A1

公开(公告)日：2016-04-21

申请号：US14894505

申请日：2014-05-28

Applicant: BRACCO IMAGING S.P.A.

Inventor： Simona GHIANI ,  Alessandro MAIOCCHI ,  Lara CAMINITI ,  Luigi MIRAGOLI

IPC: A61K49/00

CPC classification number: A61K49/0093 ,  A61K9/10 ,  A61K9/5123 ,  A61K49/0034 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0078

Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

Abstract translation: 本发明公开了一种固体脂质纳米颗粒（SLN），其包含：a）包含至少一种甘油酯和/或至少一种脂肪酸的固体脂质核; b）形成围绕所述芯a）的壳的两亲组分的混合物; c）与式I和/或II化合物的碱土络合物：d）至少一种选自以下的荧光染料：花青荧光染料和/或选自以下的多环庚烯化合物：香豆素，吡喃，喹啉，吡喃并喹啉，吲哚 和酸形式的吡喃并吲哚衍生物或其药学上可接受的盐。 这些纳米粒子允许延长的血液循环半衰期，显示增强的光稳定性和改善的荧光信号。 染料保持不劣化，提高荧光量子产率。

公开(公告)号：US20190167818A1

公开(公告)日：2019-06-06

申请号：US16263769

申请日：2019-01-31

Applicant: BRACCO IMAGING S.P.A.

Inventor： Simona GHIANI ,  Alessandro MAIOCCHI ,  Lara CAMINITI ,  Luigi MIRAGOLI

IPC: A61K49/00

Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty add; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindele derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.