公开(公告)号：US20230233681A1

公开(公告)日：2023-07-27

申请号：US18187244

申请日：2023-03-21

申请人： EXACT THERAPEUTICS AS

发明人： Andrew John HEALEY ,  Per Christian SONTUM ,  Svein KVALE

IPC分类号： A61K9/16 ,  A61K41/00 ,  A61K9/19 ,  A61K49/00 ,  A61K49/22

CPC分类号： A61K9/16 ,  A61K9/19 ,  A61K41/0047 ,  A61K49/0078 ,  A61K49/223

摘要： Disclosed herein are methods relating to manufacturing an embolizing agent precursor. Manufacture of the embolizing agent precursor may involve mixing a first component contained within a first container with a second component contained within a second container, the first component including a plurality of negatively charged gaseous components and a first stabilizer, the second component comprising a plurality of positively charged oil components, a second stabilizer, and a cationic surfactant. Further steps may include mixing the first component with the second component such that the first and second component are held together as a single agglomerated entity.

公开(公告)号：US20110200532A1

公开(公告)日：2011-08-18

申请号：US13058851

申请日：2009-08-14

申请人： Mathieu Goutayer ,  Fabrice Navarro Y Garcia ,  Isabelle Texier-Nogues

发明人： Mathieu Goutayer ,  Fabrice Navarro Y Garcia ,  Isabelle Texier-Nogues

IPC分类号： A61K49/00

CPC分类号： A61K49/0078 ,  A61K49/0034

摘要： The present invention relates to a formulation of indocyanine green in the form of a nanoemulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises indocyanine green, at least one amphiphilic lipid and at least one solubilising lipid.It relates also to a process for the preparation and to the use of the formulation.

摘要翻译： 本发明涉及纳米乳液形式的靛青绿的制剂，其包含连续的水相和至少一种分散的油相，其中油相包含靛青绿，至少一种两亲脂质和至少一种增溶脂质 。 它还涉及制备和使用制剂的方法。

公开(公告)号：US20100144899A1

公开(公告)日：2010-06-10

申请号：US12527371

申请日：2008-02-14

申请人： Mathieu Goutayer ,  Isabelle Texier-Nogues ,  Jerome Bibette

发明人： Mathieu Goutayer ,  Isabelle Texier-Nogues ,  Jerome Bibette

IPC分类号： A61K47/34 ,  A61K47/44 ,  A61P43/00

CPC分类号： A61K49/0078 ,  A61K9/1075 ,  A61K49/0032 ,  A61K49/0056 ,  B01F17/0078

摘要： The present invention relates to a method for preparing nano-emulsions comprising at least one aqueous continuous phase and at least one oily dispersed phase, comprising the steps of: (i) preparing the oily phase comprising at least one amphiphilic lipid and at least one solubilising lipid; (ii) dispersing the oily phase in an aqueous phase under the effect of sufficient shear force to form a nano-emulsion; and (iii) recovering the nano-emulsion thus formed.

摘要翻译： 本发明涉及一种制备包含至少一种含水连续相和至少一种油分散相的纳米乳液的方法，其包括以下步骤：（i）制备包含至少一种两亲脂质和至少一种增溶的油相 脂质; （ii）在足够剪切力的作用下将油相分散在水相中以形成纳米乳液; 和（iii）回收如此形成的纳米乳液。

公开(公告)号：US06319488B1

公开(公告)日：2001-11-20

申请号：US09051511

申请日：1998-04-09

申请人： Kai Licha ,  Björn Riefke ,  Werner Weitschiess ,  Dieter Heldmann ,  Violetta Sudmann

发明人： Kai Licha ,  Björn Riefke ,  Werner Weitschiess ,  Dieter Heldmann ,  Violetta Sudmann

IPC分类号： A61B1000

CPC分类号： A61K49/0032 ,  A61K49/0076 ,  A61K49/0078

摘要： This invention relates to colloidal systems charged with polymethine dyes and having suitable photophysical and pharmacological properties, their use as a contrast medium in fluorescence and transillumination diagnostics in the near infrared spectral range, as well as methods for their production.

摘要翻译： 本发明涉及装有聚甲炔染料并具有合适的光物理和药理学性质的胶体系统，它们作为近红外光谱范围的荧光和透照诊断中的造影剂的用途，以及它们的生产方法。

公开(公告)号：US20230190953A1

公开(公告)日：2023-06-22

申请号：US18054065

申请日：2022-11-09

申请人： FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA DE SANTIAGO DE COMPOSTELA (FIDIS) ,  SERVIZO GALEGO DE SAÚDE

发明人： María DE LA FUENTE FREIRE ,  Rafael LÓPEZ LÓPEZ ,  Belén LÓPEZ BOUZO ,  Abi Judit VÁZQUEZ RÍOS ,  Marta ALONSO NOCELO

IPC分类号： A61K47/69 ,  A61K47/64 ,  A61K47/54 ,  A61P35/00 ,  A61K9/107 ,  A61K31/05 ,  A61K31/12 ,  A61K31/337 ,  A61K31/513 ,  A61K31/685 ,  A61K31/7048 ,  A61K31/7068 ,  A61K41/00 ,  A61K45/06 ,  A61K47/10 ,  A61K47/22 ,  A61K47/24 ,  A61K49/00 ,  A61K51/12

CPC分类号： A61K47/6907 ,  A61K47/6425 ,  A61K47/64 ,  A61K47/549 ,  A61P35/00 ,  A61K9/1075 ,  A61K31/05 ,  A61K31/12 ,  A61K31/337 ,  A61K31/513 ,  A61K31/685 ,  A61K31/7048 ,  A61K31/7068 ,  A61K41/0071 ,  A61K45/06 ,  A61K47/10 ,  A61K47/22 ,  A61K47/24 ,  A61K49/0002 ,  A61K49/0078 ,  A61K51/122

摘要： Various oil-in-water (O/W) nanoemulsions containing an oil phase or oil core, preferably selected from vitamin E or oleic acid, stabilized by a sphingolipid of the sphingomyelin type, and optionally other lipids such as phospholipids, cholesterol, octadecylamine, DOTAP (N-[1-(2,3-Dioleoyloxy) propyl]-N, N, N-trimethylammonium methyl-sulfate), and PEGylated derivatives (derivatives with polyethylene glycol), for use as a nanotech vehicle, for example for the management of cancer and metastatic disease. Said nanoemulsions can be functionalized with ligands capable of interacting or binding to receptors expressed on the cell membrane of tumor cells, and in particular capable of interacting or binding to receptors expressed on the membrane of primary and/or disseminated or metastatic tumor cells. Also, antitumor drugs or therapeutic biomolecules can be encapsulated in said nanoemulsions and, finally, contrast agents can be incorporated for their use in the in vivo diagnosis in said nanoemulsions.

公开(公告)号：US20180185282A1

公开(公告)日：2018-07-05

申请号：US15856786

申请日：2017-12-28

申请人： UNIVERSIDAD DE CHILE

发明人： Simón Juan GUERRERO RIVERA ,  Pamela Paz CONTRERAS ORELLANA ,  Victor DÍAZ GARCÍA ,  Pablo Alberto LARA ARENAS ,  Areli Marly ANDREA ,  Lisette LEYTON CAMPOS ,  Marcelo Javier KOGAN BOSIAN ,  Andrew F.G. QUEST ,  Felipe Andrés OYARZÚN AMPUERO ,  Andrea I. VIVANCO PALMA ,  Víctor Andrés MIRANDA MIRANDA

IPC分类号： A61K9/107 ,  A61K31/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/08 ,  A61K47/10 ,  A61K49/00 ,  A61P35/04

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K31/12 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/44 ,  A61K49/0021 ,  A61K49/0078 ,  A61P35/04

摘要： A oil-in-water curcumin nanoemulsion that includes curcumin dissolved in at least one miscible solvent and encapsulated in an oil core, wherein the oil core also comprises a stabilizer, wherein the oil core forms an organic phase which is dispersed in an aqueous solvent, and wherein the oil core is selected from a pharmaceutically acceptable oil. A method of manufacturing an oil-in-water curcumin nanoemulsion includes dissolving the curcumin in at least one miscible solvent; encapsulating the curcumin in the oil core to produce an organic phase solution; adding the stabilizer to the organic phase solution; dispersing the organic phase solution in the aqueous solvent; and evaporating the mixture. A method of preventing metastatic cancer using an oil-in-water curcumin nanoemulsion by administering an amount of the nanoemulsion topically to an area of an excised primary tumor, and monitoring any reincidence of metastatic cancer in the excised primary tumor area.

公开(公告)号：US09289517B2

公开(公告)日：2016-03-22

申请号：US13058851

申请日：2009-08-14

申请人： Mathieu Goutayer ,  Fabrice Navarro Y Garcia ,  Isabelle Texier-Nogues

发明人： Mathieu Goutayer ,  Fabrice Navarro Y Garcia ,  Isabelle Texier-Nogues

IPC分类号： A61K49/00

CPC分类号： A61K49/0078 ,  A61K49/0034

摘要： The present invention relates to a formulation of indocyanine green in the form of a nanoemulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises indocyanine green, at least one amphiphilic lipid and at least one solubilizing lipid.It relates also to a process for the preparation and to the use of the formulation.

摘要翻译： 本发明涉及纳米乳液形式的靛青绿的制剂，其包含连续水相和至少一种分散的油相，其中油相包含靛青绿，至少一种两亲脂质和至少一种增溶脂质 。 它还涉及制备和使用制剂的方法。

公开(公告)号：US20110110867A1

公开(公告)日：2011-05-12

申请号：US13000197

申请日：2009-06-19

申请人： Bong Hyun Chung ,  Yong Taik Lim

发明人： Bong Hyun Chung ,  Yong Taik Lim

IPC分类号： A61K49/06 ,  A61K49/00 ,  B82Y15/00

CPC分类号： A61K49/0078 ,  A61K49/0002 ,  A61K49/0017 ,  A61K49/0067 ,  A61K49/1806

摘要： The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varying the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted.

摘要翻译： 本发明涉及使用包含光学纳米颗粒和全氟化碳的纳米乳液的多模式成像方法，更具体地说，涉及使用由全氟化碳组成的纳米乳液用于多光谱磁共振成像（MRI）和 用于多色荧光检测的纳米颗粒。 在多模式成像方法中，通过改变全氟化碳的种类和组合以及光学纳米颗粒的种类和组合，可以获得各种多光谱MRI图像和多色荧光光谱，从而可以进行多重分析。 因此，多模式成像方法可以应用于已经进行细胞分子成像研究的生物和医学领域的各个领域。

公开(公告)号：US06662040B1

公开(公告)日：2003-12-09

申请号：US09458008

申请日：1999-12-10

申请人： Paul Mark Henrichs ,  Marten Eriksen ,  Pal Rongved ,  Wolfgang Hans Heinrich Gunther ,  Robert Allen Snow ,  Kenneth Robert Hollister ,  Gregory Lynn McIntire ,  Steven Blair Coffey

发明人： Paul Mark Henrichs ,  Marten Eriksen ,  Pal Rongved ,  Wolfgang Hans Heinrich Gunther ,  Robert Allen Snow ,  Kenneth Robert Hollister ,  Gregory Lynn McIntire ,  Steven Blair Coffey

IPC分类号： A61B600

CPC分类号： A61K41/00 ,  A61B6/508 ,  A61K49/00 ,  A61K49/0002 ,  A61K49/0034 ,  A61K49/0078 ,  A61K49/0084 ,  A61K49/0091 ,  A61K49/0404 ,  A61K49/0438 ,  A61K49/0466 ,  Y10S977/949

摘要： The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.

摘要翻译： 本发明涉及一种产生动物人或非人动物体或其一部分的图像的方法。 该方法包括向所述身体施用包含辐射吸收组分和/或压力诱导组分的生理学可耐受的造影剂，将所述身体暴露于辐射，通过所述辐射检测在所述身体中产生的压力波并至少产生至少一个光声影像 所述身体的一部分包含施用的造影剂。

公开(公告)号：US20180126011A1

公开(公告)日：2018-05-10

申请号：US15571528

申请日：2016-05-19

申请人： UNIVERSITE D'AVIGNON ET DES PAYS DU VAUCLUSE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Stéphane DESGRANGES ,  Wlodzimierz URBACH ,  Lucie SOMAGLINO ,  Nicolas TAULIER ,  Christiane PEPIN

IPC分类号： A61K49/18 ,  A61K47/54 ,  A61K41/00 ,  A61K47/62 ,  A61K47/69 ,  A61K49/00 ,  A61K49/22 ,  B01J31/06 ,  C08G83/00

CPC分类号： A61K49/1806 ,  A61K41/0028 ,  A61K41/0033 ,  A61K47/549 ,  A61K47/62 ,  A61K47/6907 ,  A61K49/0028 ,  A61K49/0036 ,  A61K49/0078 ,  A61K49/226 ,  B01J31/064 ,  C08G83/003 ,  C08G83/004 ,  C08G83/008

摘要： The present invention relates to novel amphiphilic dendrimers, hereafter denoted Dendri-TAC. The present invention also relates to perfluorocarbon nanoemulsions stabilized by these amphiphilic dendrimers and their uses for in vivo diagnostic and/or for therapy, notably as theranostic tools, for detection and/or treatment of cancer.