公开(公告)号：US20210292762A1

公开(公告)日：2021-09-23

申请号：US17262835

申请日：2019-07-24

Applicant: BRACCO IMAGING S.P.A.

Inventor： Vittorio DE FRANCISCIS ,  Silvia CATUOGNO ,  Carla Lucia ESPOSITO ,  Alessandro MAIOCCHI ,  Margherita IABONI ,  Luisa POGGI ,  Erika REITANO

IPC: C12N15/115

Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.

公开(公告)号：US20230203129A1

公开(公告)日：2023-06-29

申请号：US17786669

申请日：2020-12-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Erika REITANO ,  Alessandro MAIOCCHI ,  Luisa POGGI ,  Federico CRIVELLIN ,  Simon HUET ,  Mathieu CINIER ,  Olivier KITTEN

IPC: C07K14/71 ,  C07K1/13 ,  G01N33/533

CPC classification number: C07K14/71 ,  C07K1/13 ,  G01N33/533

Abstract: The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.

公开(公告)号：US20170340755A1

公开(公告)日：2017-11-30

申请号：US15535937

申请日：2015-12-18

Applicant: BRACCO IMAGING S.P.A.

Inventor： Alessandro MAIOCCHI ,  Chiara BRIOSCHI ,  Fulvio UGGERI ,  Giovanni VALBUSA

IPC: A61K49/00 ,  A61B10/00 ,  A61B5/08 ,  A61B5/00

Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence- guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.

公开(公告)号：US20220062444A1

公开(公告)日：2022-03-03

申请号：US17414508

申请日：2019-12-17

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Giuseppe FERRAUTO ,  Eliana GIANOLIO ,  Luciano LATTUADA ,  Alessandro MAIOCCHI

IPC: A61K49/10 ,  A61K47/20

Abstract: The present invention refers to pharmaceutical compositions comprising a macrocyclic gadolinium complex and a water-soluble polyarylene additive useful in diagnostic imaging as diagnostic agents, in particular as contrast agents, specifically in Magnetic Resonance Imaging (MRI).

公开(公告)号：US20190167818A1

公开(公告)日：2019-06-06

申请号：US16263769

申请日：2019-01-31

Applicant: BRACCO IMAGING S.P.A.

Inventor： Simona GHIANI ,  Alessandro MAIOCCHI ,  Lara CAMINITI ,  Luigi MIRAGOLI

IPC: A61K49/00

Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty add; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindele derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

公开(公告)号：US20170252464A1

公开(公告)日：2017-09-07

申请号：US15500024

申请日：2015-07-22

Applicant: BRACCO IMAGING S.P.A. ,  UNIVERSITA DI PAVIA

Inventor： Elena ELISEI ,  Attilio CESARO ,  Marta FILIBIAN ,  Pietro CARRETTA ,  Sonia COLOMBO SERRA ,  Alessandro MAIOCCHI ,  Fabio TEDOLDI

IPC: A61K49/10 ,  A61K49/18

CPC classification number: A61K49/10 ,  A61K49/18

Abstract: A method for preparing a sample for dynamic nuclear polarization which comprises submitting a solid substrate to a milling process in the presence of a polarizing agent at a temperature lower than the glass-transition temperature (Tg) of said substrate. Preferably said substrate may be in crystalline form.

公开(公告)号：US20230040008A1

公开(公告)日：2023-02-09

申请号：US17786768

申请日：2020-12-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Erika REITANO ,  Alessandro MAIOCCHI ,  Luisa POGGI ,  Federico CRIVELLIN ,  Simon HUET ,  Mathieu CINIER ,  Olivier KITTEN

IPC: C07K14/00 ,  A61K49/00 ,  C07K1/13

Abstract: The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.

公开(公告)号：US20220348923A1

公开(公告)日：2022-11-03

申请号：US17642753

申请日：2020-09-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Vittorio DE FRANCISCIS ,  Carla Lucia ESPOSITO ,  Silvia CATUOGNO ,  Silvia NUZZO ,  Alessandro MAIOCCHI ,  Margherita IABONI ,  Aldo DI VITO ,  Erika REITANO ,  Luisa POGGI

IPC: C12N15/115 ,  C12Q1/6886 ,  A61K45/06

Abstract: The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing CA-IX, or as therapeutic agents for prevention or treatment of CA-IX related diseases.

公开(公告)号：US20180036436A1

公开(公告)日：2018-02-08

申请号：US15551612

申请日：2016-02-25

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Zoltán GARDA ,  Simona GHIANI ,  Ferenc Krisztián KÁLMÁN ,  László KRUSPER ,  Alessandro MAIOCCHI ,  Gyula TIRCSÓ ,  Imre TOTH

IPC: A61K49/10 ,  C07D295/185 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D207/34 ,  C07D211/62 ,  C07D211/16 ,  C07D295/192 ,  C07D491/107 ,  C07D221/22 ,  C07D471/08 ,  G01N33/58 ,  G01N24/08 ,  A61B5/055 ,  C07D207/325

CPC classification number: A61K49/106 ,  A61B5/055 ,  A61B2503/40 ,  A61K49/103 ,  C07C237/06 ,  C07D207/325 ,  C07D207/34 ,  C07D211/16 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D211/62 ,  C07D221/22 ,  C07D295/185 ,  C07D295/192 ,  C07D401/12 ,  C07D403/12 ,  C07D471/08 ,  C07D491/107 ,  G01N24/08 ,  G01N33/58

Abstract: The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.

公开(公告)号：US20160106869A1

公开(公告)日：2016-04-21

申请号：US14894505

申请日：2014-05-28

Applicant: BRACCO IMAGING S.P.A.

Inventor： Simona GHIANI ,  Alessandro MAIOCCHI ,  Lara CAMINITI ,  Luigi MIRAGOLI

IPC: A61K49/00

CPC classification number: A61K49/0093 ,  A61K9/10 ,  A61K9/5123 ,  A61K49/0034 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0078

Abstract: The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

Abstract translation: 本发明公开了一种固体脂质纳米颗粒（SLN），其包含：a）包含至少一种甘油酯和/或至少一种脂肪酸的固体脂质核; b）形成围绕所述芯a）的壳的两亲组分的混合物; c）与式I和/或II化合物的碱土络合物：d）至少一种选自以下的荧光染料：花青荧光染料和/或选自以下的多环庚烯化合物：香豆素，吡喃，喹啉，吡喃并喹啉，吲哚 和酸形式的吡喃并吲哚衍生物或其药学上可接受的盐。 这些纳米粒子允许延长的血液循环半衰期，显示增强的光稳定性和改善的荧光信号。 染料保持不劣化，提高荧光量子产率。