公开(公告)号：US10457635B2

公开(公告)日：2019-10-29

申请号：US15853506

申请日：2017-12-22

申请人： BRACCO IMAGING S.p.A.

发明人： Pier Lucio Anelli ,  Maria Argese ,  Valeria Boi ,  Livio Cavalieri ,  Laura Galimberti ,  Sonia Gazzetto ,  Luciano Lattuada ,  Federico Maisano ,  Giovanni Rivolta ,  Fulvia Vella

IPC分类号： C07C303/24 ,  C07C227/16 ,  A61K9/20 ,  A61K31/198 ,  C07D495/04 ,  C07F1/04

摘要： The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chlorosulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields.The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets.Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives.

公开(公告)号：US11667601B2

公开(公告)日：2023-06-06

申请号：US17786623

申请日：2020-12-17

申请人： BRACCO IMAGING S.P.A.

发明人： Andrea Banin ,  Laura Galimberti ,  Roberta Napolitano ,  Roberta Fretta

IPC分类号： C07C229/22 ,  C07C227/18

CPC分类号： C07C229/22 ,  C07C227/18

摘要： The present invention relates to the calcium complex of (4RS)(4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl oxa-5,8,11-triazatridecan-13-oato(5-))pentahydrogen (BOPTA) in the form of a salt, to the process for its preparation and to a formulation comprising said salt.