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    Manufacturing process for preparing gadoteridol
    1.
    发明授权
    Manufacturing process for preparing gadoteridol 有权

    公开(公告)号：US11905257B2

    公开(公告)日：2024-02-20

    申请号：US18039540

    申请日：2021-12-01

    申请人： BRACCO IMAGING S.P.A.

    发明人： Roberta Fretta ,  Luciano Lattuada ,  Gabriele Meli

    IPC分类号： C07D257/02

    CPC分类号： C07D257/02

    摘要： The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.

    Preparation of a solid form of gadobenate dimeglumine
    5.
    发明授权
    Preparation of a solid form of gadobenate dimeglumine 有权

    公开(公告)号：US10519171B2

    公开(公告)日：2019-12-31

    申请号：US15321176

    申请日：2015-07-20

    申请人： BRACCO IMAGING S.P.A.

    发明人： Roberta Mazzon ,  Roberta Fretta ,  Pier Lucio Anelli

    IPC分类号： C07F5/00 ,  A61K49/10 ,  A61K49/18

    摘要： The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.

    Preparation of a solid form of gadobenate dimeglumine
    6.
    发明授权
    Preparation of a solid form of gadobenate dimeglumine 有权

    公开(公告)号：US11014942B2

    公开(公告)日：2021-05-25

    申请号：US16678082

    申请日：2019-11-08

    申请人： BRACCO IMAGING S.P.A.

    发明人： Roberta Mazzon ,  Roberta Fretta ,  Pier Lucio Anelli

    IPC分类号： C07F5/00 ,  A61K9/14 ,  A61K9/00 ,  C07C227/40 ,  A61K49/10 ,  A61K49/18

    摘要： The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.