公开(公告)号：US20220348923A1

公开(公告)日：2022-11-03

申请号：US17642753

申请日：2020-09-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Vittorio DE FRANCISCIS ,  Carla Lucia ESPOSITO ,  Silvia CATUOGNO ,  Silvia NUZZO ,  Alessandro MAIOCCHI ,  Margherita IABONI ,  Aldo DI VITO ,  Erika REITANO ,  Luisa POGGI

IPC: C12N15/115 ,  C12Q1/6886 ,  A61K45/06

Abstract: The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing CA-IX, or as therapeutic agents for prevention or treatment of CA-IX related diseases.

公开(公告)号：US20210292762A1

公开(公告)日：2021-09-23

申请号：US17262835

申请日：2019-07-24

Applicant: BRACCO IMAGING S.P.A.

Inventor： Vittorio DE FRANCISCIS ,  Silvia CATUOGNO ,  Carla Lucia ESPOSITO ,  Alessandro MAIOCCHI ,  Margherita IABONI ,  Luisa POGGI ,  Erika REITANO

IPC: C12N15/115

Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.