公开(公告)号：US20230203129A1

公开(公告)日：2023-06-29

申请号：US17786669

申请日：2020-12-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Erika REITANO ,  Alessandro MAIOCCHI ,  Luisa POGGI ,  Federico CRIVELLIN ,  Simon HUET ,  Mathieu CINIER ,  Olivier KITTEN

IPC: C07K14/71 ,  C07K1/13 ,  G01N33/533

CPC classification number: C07K14/71 ,  C07K1/13 ,  G01N33/533

Abstract: The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.

公开(公告)号：US20210292762A1

公开(公告)日：2021-09-23

申请号：US17262835

申请日：2019-07-24

Applicant: BRACCO IMAGING S.P.A.

Inventor： Vittorio DE FRANCISCIS ,  Silvia CATUOGNO ,  Carla Lucia ESPOSITO ,  Alessandro MAIOCCHI ,  Margherita IABONI ,  Luisa POGGI ,  Erika REITANO

IPC: C12N15/115

Abstract: The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.

公开(公告)号：US20230040008A1

公开(公告)日：2023-02-09

申请号：US17786768

申请日：2020-12-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Erika REITANO ,  Alessandro MAIOCCHI ,  Luisa POGGI ,  Federico CRIVELLIN ,  Simon HUET ,  Mathieu CINIER ,  Olivier KITTEN

IPC: C07K14/00 ,  A61K49/00 ,  C07K1/13

Abstract: The present invention provides new polypeptide derivatives binding to Human Epidermal Growth Factor Receptor 2 (HER2) and their conjugates thereof, and to their use as a diagnostic agent, particularly for early detection, patient stratification and treatment monitoring of forms of cancer characterized by over-expression of HER2.

公开(公告)号：US20220348923A1

公开(公告)日：2022-11-03

申请号：US17642753

申请日：2020-09-16

Applicant: BRACCO IMAGING S.P.A.

Inventor： Vittorio DE FRANCISCIS ,  Carla Lucia ESPOSITO ,  Silvia CATUOGNO ,  Silvia NUZZO ,  Alessandro MAIOCCHI ,  Margherita IABONI ,  Aldo DI VITO ,  Erika REITANO ,  Luisa POGGI

IPC: C12N15/115 ,  C12Q1/6886 ,  A61K45/06

Abstract: The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing CA-IX, or as therapeutic agents for prevention or treatment of CA-IX related diseases.