公开(公告)号：US11591392B2

公开(公告)日：2023-02-28

申请号：US16697653

申请日：2019-11-27

Applicant: Bristol-Myers Squibb Company

Inventor： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F. Ardourel ,  Ekaterina Deyanova ,  Richard Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Truong

IPC: A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  A61K47/68 ,  G01N33/574 ,  A61K39/00

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

公开(公告)号：US10533052B2

公开(公告)日：2020-01-14

申请号：US16017489

申请日：2018-06-25

Applicant: Bristol-Myers Squibb Company

Inventor： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F. Ardourel ,  Ekaterina Deyanova ,  Richard Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Truong

IPC: C07K16/30 ,  C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  G01N33/574 ,  A61K39/00

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

公开(公告)号：US12129297B2

公开(公告)日：2024-10-29

申请号：US16961545

申请日：2019-01-11

Applicant: Bristol-Myers Squibb Company

Inventor： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F. Ardourel ,  Ekaterina Deyanova ,  Richard Yu-Cheng Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Truong

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/68 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61P35/00 ,  G01N33/6854 ,  A61K2039/507 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/70503

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

公开(公告)号：US10023634B2

公开(公告)日：2018-07-17

申请号：US15649380

申请日：2017-07-13

Applicant: Bristol-Myers Squibb Company

Inventor： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F. Ardourel ,  Ekaterina Deyanova ,  Richard Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Troung

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

公开(公告)号：US12139551B2

公开(公告)日：2024-11-12

申请号：US17299038

申请日：2019-12-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Anan Chuntharapai ,  Paul Blaine Mesko ,  Thomas E. Spires, Jr. ,  Gaby A. Terracina ,  Xi-Tao Wang

IPC: C07K16/00 ,  A61P35/00 ,  C07K16/40 ,  G01N1/30 ,  G01N33/574

Abstract: The disclosure provides antibodies that specifically bind human IDO and methods of use thereof. In some aspects, the disclosure is directed to methods of detecting IDO in a biological sample comprising contacting the biological sample with an antibody described herein.

公开(公告)号：US20180298097A1

公开(公告)日：2018-10-18

申请号：US16017489

申请日：2018-06-25

Applicant: Bristol-Myers Squibb Company

Inventor： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F,. Ardourel ,  Ekaterina Deyanova ,  Richard Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Troung

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

公开(公告)号：US10077306B2

公开(公告)日：2018-09-18

申请号：US15649380

申请日：2017-07-13

Applicant: Bristol-Myers Squibb Company

Inventor： Xiao Min Schebye ,  Mark J. Selby ,  Michelle Minhua Han ,  Christine Bee ,  Andy X. Deng ,  Anan Chuntharapai ,  Brigitte Devaux ,  Huiming Li ,  Paul O. Sheppard ,  Alan J. Korman ,  Daniel F. Ardourel ,  Ekaterina Deyanova ,  Richard Huang ,  Guodong Chen ,  Michelle Kuhne ,  Hong-An Troung

IPC: C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/3046 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.