公开(公告)号：US20210147383A1

公开(公告)日：2021-05-20

申请号：US16950978

申请日：2020-11-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew P. DEGNAN ,  Godwin Kwame Kumi ,  Audris Huang ,  James Aaron Balog ,  Ashok Vinayak Purandare ,  Weifang Shan ,  Guo Li

IPC: C07D401/14 ,  C07D405/14 ,  C07D487/04 ,  C07D417/14 ,  C07D498/18

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR6R6 or C═O; Ring A is: and R1, R2, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.