公开(公告)号：US20160257645A1

公开(公告)日：2016-09-08

申请号：US15031352

申请日：2014-10-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Annapurna Pendri ,  Guo Li ,  John A. Bender ,  Zhong Yang ,  Alan Xiangdong Wang ,  Brett R. Beno ,  Robert A. Fridell ,  Makonen Belema ,  Nicholas A. Meanwell ,  Robert G. Gentles

IPC: C07C311/58 ,  C07D317/66 ,  C07D409/12 ,  C07D405/12 ,  C07D317/46 ,  C07D407/12 ,  C07D271/06 ,  C07D307/38 ,  C07D333/18 ,  C07D231/12 ,  C07D333/54 ,  C07D209/10 ,  C07D333/28 ,  C07D261/08 ,  C07D215/08 ,  C07D209/08 ,  C07D277/82 ,  C07D495/04 ,  C07D491/08 ,  C07D205/04 ,  C07D401/04 ,  C07D213/56 ,  C07D249/08 ,  C07D265/36

CPC classification number: C07C311/58 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D205/04 ,  C07D209/08 ,  C07D209/10 ,  C07D213/56 ,  C07D215/08 ,  C07D231/12 ,  C07D249/08 ,  C07D261/08 ,  C07D265/36 ,  C07D271/06 ,  C07D277/82 ,  C07D307/38 ,  C07D317/46 ,  C07D317/66 ,  C07D333/18 ,  C07D333/28 ,  C07D333/54 ,  C07D401/04 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D491/08 ,  C07D495/04

Abstract: Compounds of Formula I with activity against HIV, including pharmaceutical compositions and methods for using these compounds in treating human immunodeficiency virus (HIV) infection, are set forth: Formula: (I)

Abstract translation: 阐述了具有抗HIV活性的式I化合物，包括药物组合物和使用这些化合物治疗人类免疫缺陷病毒（HIV）感染的方法：式（I）

公开(公告)号：US20210147383A1

公开(公告)日：2021-05-20

申请号：US16950978

申请日：2020-11-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew P. DEGNAN ,  Godwin Kwame Kumi ,  Audris Huang ,  James Aaron Balog ,  Ashok Vinayak Purandare ,  Weifang Shan ,  Guo Li

IPC: C07D401/14 ,  C07D405/14 ,  C07D487/04 ,  C07D417/14 ,  C07D498/18

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR6R6 or C═O; Ring A is: and R1, R2, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US09034882B2

公开(公告)日：2015-05-19

申请号：US13782198

申请日：2013-03-01

Applicant: Bristol-Myers Squibb Company

Inventor： Annapurna Pendri ,  David R. Langley ,  Samuel Gerritz ,  Guo Li ,  Weixu Zhai ,  Stanley D'Andrea ,  Manoj Patel ,  B. Narasimhulu Naidu ,  Kevin Peese ,  Zhongyu Wang

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  C07D487/04 ,  C07D498/08 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D498/08 ,  C07D519/00

Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

公开(公告)号：US20130231331A1

公开(公告)日：2013-09-05

申请号：US13782198

申请日：2013-03-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Annapurna Pendri ,  David R. Langley ,  Samuel Gerritz ,  Guo Li ,  Weixu Zhai ,  Stanley D'Andrea ,  Manoj Patel ,  B. Narasimhulu Naidu ,  Kevin Peese ,  Zhongyu Wang

IPC: C07D487/04 ,  C07D498/08

CPC classification number: C07D487/04 ,  C07D498/08 ,  C07D519/00

Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。

公开(公告)号：US11548870B2

公开(公告)日：2023-01-10

申请号：US16950978

申请日：2020-11-18

Applicant: Bristol-Myers Squibb Company

Inventor： Andrew P. Degnan ,  Godwin Kwame Kumi ,  Audris Huang ,  James Aaron Balog ,  Ashok Vinayak Purandare ,  Weifang Shan ,  Guo Li

IPC: C07D407/14 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D491/107 ,  A61K31/4439 ,  A61P35/00 ,  C07D405/14 ,  C07D498/18

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR6R6 or C═O; Ring A is: and R1, R2, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.