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公开(公告)号：US20190248893A1
公开(公告)日：2019-08-15
申请号：US16316991
申请日：2017-07-13
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Y. HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
IPC: C07K16/28 , A61K47/68 , A61P35/00 , G01N33/574
CPC classification number: C07K16/2803 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/30 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/57492
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20190135932A1
公开(公告)日：2019-05-09
申请号：US16245816
申请日：2019-01-11
Applicant: Pfizer Inc. , Bristol-Myers Squibb Company
Inventor： Jing MIN , Yanli WU , Rory F. FINN , Barrett R. THIELE , Wei LIAO , Ronald P. GLADUE , Arvind RAJPAL , Timothy J. PARADIS , Peter BRAMS , Brigitte DEVAUX , Yi WU , Kristopher TOY , Heidi N. LEBLANC , Haichun HUANG
IPC: C07K16/28
Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
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公开(公告)号：US20240209083A1
公开(公告)日：2024-06-27
申请号：US18481884
申请日：2023-10-05
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Y. HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
CPC classification number: C07K16/2803 , A61K47/6849 , A61P35/00 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/30 , C07K16/3046 , G01N33/57492 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20220002428A1
公开(公告)日：2022-01-06
申请号：US17373965
申请日：2021-07-13
Applicant: Pfizer Inc. , Bristol-Myers Squibb Company
Inventor： Jing MIN , Yanli WU , Rory F. FINN , Barrett R. THIELE , Wei LIAO , Ronald P. GLADUE , Arvind RAJPAL , Timothy J. PARADIS , Peter BRAMS , Brigitte DEVAUX , Yi WU , Kristopher TOY , Heidi N. LEBLANC , Haichun HUANG
IPC: C07K16/28
Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
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公开(公告)号：US20240174749A1
公开(公告)日：2024-05-30
申请号：US18476098
申请日：2023-09-27
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Yu-Cheng HUANG , Guodong CHEN , Michelle Renne KUHNE , Hong-An TRUONG , Poliana PATAH , Jeffrey R. JACKSON , Ronald A. FLEMING
IPC: C07K16/28 , A61K39/00 , A61K39/395 , A61P35/00
CPC classification number: C07K16/2803 , A61K39/3955 , A61P35/00 , C07K16/2818 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/21 , C07K2317/52 , C07K2317/565
Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.
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Patent Agency Ranking
公开(公告)号：US20230382992A1
公开(公告)日：2023-11-30
申请号：US18175420
申请日：2023-02-27
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
IPC: C07K16/28 , C07K16/30 , A61K47/68 , A61P35/00 , G01N33/574
CPC classification number: C07K16/2803 , C07K16/2827 , C07K16/30 , C07K16/3046 , A61K47/6849 , A61P35/00 , C07K16/2818 , C07K16/2878 , G01N33/57492 , A61K2039/507
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20250115664A1
公开(公告)日：2025-04-10
申请号：US18891677
申请日：2024-09-20
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Yu-Cheng HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.
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公开(公告)号：US20240336695A1
公开(公告)日：2024-10-10
申请号：US18640480
申请日：2024-04-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Bryan C. BARNHART , Brigitte DEVAUX , Aaron P. YAMNIUK , Shannon L. OKADA , Brenda L. STEVENS
CPC classification number: C07K16/2878 , A61P31/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92 , C07K2317/94
Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
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公开(公告)号：US20180142030A1
公开(公告)日：2018-05-24
申请号：US15579450
申请日：2016-06-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Bryan C. BARNHART , Brigitte DEVAUX , Aaron P. YAMNIUK , Shannon L. OKADA , Brenda L. STEVENS
CPC classification number: C07K16/2878 , A61K2039/505 , A61P31/12 , A61P35/00 , A61P35/02 , A61P35/04 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92 , C07K2317/94
Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
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公开(公告)号：US20180016336A1
公开(公告)日：2018-01-18
申请号：US15649380
申请日：2017-07-13
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TROUNG
CPC classification number: C07K16/2803 , A61K2039/505 , A61K2039/507 , C07K16/2827 , C07K16/30 , C07K16/3046 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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