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公开(公告)号：US20190248893A1
公开(公告)日：2019-08-15
申请号：US16316991
申请日：2017-07-13
发明人： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Y. HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
IPC分类号： C07K16/28 , A61K47/68 , A61P35/00 , G01N33/574
CPC分类号： C07K16/2803 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/30 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/57492
摘要： Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20190135932A1
公开(公告)日：2019-05-09
申请号：US16245816
申请日：2019-01-11
发明人： Jing MIN , Yanli WU , Rory F. FINN , Barrett R. THIELE , Wei LIAO , Ronald P. GLADUE , Arvind RAJPAL , Timothy J. PARADIS , Peter BRAMS , Brigitte DEVAUX , Yi WU , Kristopher TOY , Heidi N. LEBLANC , Haichun HUANG
IPC分类号： C07K16/28
摘要： The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
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公开(公告)号：US20240209083A1
公开(公告)日：2024-06-27
申请号：US18481884
申请日：2023-10-05
发明人： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Y. HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
CPC分类号： C07K16/2803 , A61K47/6849 , A61P35/00 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/30 , C07K16/3046 , G01N33/57492 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20220002428A1
公开(公告)日：2022-01-06
申请号：US17373965
申请日：2021-07-13
发明人： Jing MIN , Yanli WU , Rory F. FINN , Barrett R. THIELE , Wei LIAO , Ronald P. GLADUE , Arvind RAJPAL , Timothy J. PARADIS , Peter BRAMS , Brigitte DEVAUX , Yi WU , Kristopher TOY , Heidi N. LEBLANC , Haichun HUANG
IPC分类号： C07K16/28
摘要： The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.
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公开(公告)号：US20240174749A1
公开(公告)日：2024-05-30
申请号：US18476098
申请日：2023-09-27
发明人： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Yu-Cheng HUANG , Guodong CHEN , Michelle Renne KUHNE , Hong-An TRUONG , Poliana PATAH , Jeffrey R. JACKSON , Ronald A. FLEMING
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2803 , A61K39/3955 , A61P35/00 , C07K16/2818 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/21 , C07K2317/52 , C07K2317/565
摘要： This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.
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公开(公告)号：US20230382992A1
公开(公告)日：2023-11-30
申请号：US18175420
申请日：2023-02-27
发明人： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
IPC分类号： C07K16/28 , C07K16/30 , A61K47/68 , A61P35/00 , G01N33/574
CPC分类号： C07K16/2803 , C07K16/2827 , C07K16/30 , C07K16/3046 , A61K47/6849 , A61P35/00 , C07K16/2818 , C07K16/2878 , G01N33/57492 , A61K2039/507
摘要： Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20240336695A1
公开(公告)日：2024-10-10
申请号：US18640480
申请日：2024-04-19
CPC分类号： C07K16/2878 , A61P31/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92 , C07K2317/94
摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
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公开(公告)号：US20180142030A1
公开(公告)日：2018-05-24
申请号：US15579450
申请日：2016-06-28
CPC分类号： C07K16/2878 , A61K2039/505 , A61P31/12 , A61P35/00 , A61P35/02 , A61P35/04 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/75 , C07K2317/92 , C07K2317/94
摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
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公开(公告)号：US20180016336A1
公开(公告)日：2018-01-18
申请号：US15649380
申请日：2017-07-13
发明人： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TROUNG
CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/507 , C07K16/2827 , C07K16/30 , C07K16/3046 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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10.发明申请公开(公告)号：US20220390463A1
公开(公告)日：2022-12-08
申请号：US17815802
申请日：2022-07-28
发明人： Robert ARCH , Jun ZHANG , Michelle MADER , Tetsuya ISHINO , Joel BARD , William FINLAY , Orla CUNNINGHAM , Ciara REILLY , Peter BRAMS , Brigitte DEVAUX , Haichun HUANG , Karla HENNING
摘要： The present invention provides antibodies, or antigen-binding fragment thereof, which specifically bind to tumor necrosis factor (TNF)-like ligand (TL1A). The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of TL1A mediated diseases, disorders or conditions.
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