公开(公告)号：US20240336695A1

公开(公告)日：2024-10-10

申请号：US18640480

申请日：2024-04-19

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Bryan C. BARNHART ,  Brigitte DEVAUX ,  Aaron P. YAMNIUK ,  Shannon L. OKADA ,  Brenda L. STEVENS

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04

CPC分类号： C07K16/2878 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2317/94

摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US20180142030A1

公开(公告)日：2018-05-24

申请号：US15579450

申请日：2016-06-28

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Bryan C. BARNHART ,  Brigitte DEVAUX ,  Aaron P. YAMNIUK ,  Shannon L. OKADA ,  Brenda L. STEVENS

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61P31/12 ,  A61P35/02 ,  A61P35/04

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2317/94

摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US20220324989A1

公开(公告)日：2022-10-13

申请号：US17694890

申请日：2022-03-15

申请人： Bristol-Myers Squibb Company ,  CytomX Therapeutics, Inc.

发明人： Bryan C. BARNHART ,  Brigitte DEVAUX ,  Aaron P. YAMNIUK ,  Shannon L. OKADA ,  Brenda L. STEVENS ,  James William WEST

IPC分类号： C07K16/28 ,  C12N15/63

摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US20210054091A1

公开(公告)日：2021-02-25

申请号：US17091375

申请日：2020-11-06

申请人： Bristol-Myers Squibb Company

发明人： Bryan C. BARNHART ,  Brigitte DEVAUX ,  Aaron P. YAMNIUK ,  Shannon L. OKADA ,  Brenda L. STEVENS

IPC分类号： C07K16/28 ,  A61P31/12 ,  A61P35/02 ,  A61P35/04 ,  A61P35/00

摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

公开(公告)号：US20200339700A1

公开(公告)日：2020-10-29

申请号：US16958563

申请日：2018-12-27

申请人： Bristol-Myers Squibb Company ,  CytomX Therapeutics, Inc.

发明人： Bryan C. BARNHART ,  Brigitte DEVAUX ,  Aaron P. YAMNIUK ,  Shannon L. OKADA ,  Brenda L. STEVENS ,  James William WEST

IPC分类号： C07K16/28 ,  C12N15/63

摘要： Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40 and comprise improved heavy and light chain variable regions that impart improved yield and reduced aggregation. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.