公开(公告)号：US10774130B2

公开(公告)日：2020-09-15

申请号：US15866919

申请日：2018-01-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  Eric Furfine ,  Irvith M. Carvajal ,  H. Nicholas Marsh ,  Marco Gottardis ,  Joan Carboni ,  Ricardo Attar

IPC: C07K14/05 ,  C07K14/78 ,  C07K16/46 ,  C07K16/28 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/39 ,  A61K47/60 ,  A61K39/395 ,  C07K14/71 ,  C07K14/715 ,  A61K39/00

Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.

公开(公告)号：US09902762B2

公开(公告)日：2018-02-27

申请号：US14229415

申请日：2014-03-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  Eric Furfine ,  Irvith M. Carvajal ,  H. Nicholas Marsh ,  Marco Gottardis ,  Joan Carboni ,  Ricardo Attar

IPC: C07K14/705 ,  C07K14/78 ,  C07K14/435 ,  C07K16/46 ,  C07K16/28 ,  A61K38/39 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K47/60 ,  A61K39/395 ,  C07K14/71 ,  C07K14/715 ,  A61K39/00

CPC classification number: C07K14/78 ,  A61K38/39 ,  A61K39/3955 ,  A61K47/60 ,  A61K2039/505 ,  C07K14/71 ,  C07K14/715 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/00 ,  C07K2319/74

Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.