公开(公告)号：US10934572B2

公开(公告)日：2021-03-02

申请号：US16244921

申请日：2019-01-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael L. Gosselin ,  David Fabrizio ,  Joanna F. Swain ,  Tracy Mitchell ,  Ray Camphausen ,  Sharon T. Cload ,  Eric Furfine ,  Paul E. Morin ,  Ranjan Mukherjee ,  Simeon I. Taylor

IPC: C12P21/00 ,  C12N15/62 ,  A61K47/62 ,  A61K47/64 ,  C07K14/78 ,  C07K14/435 ,  C07K14/50 ,  C07K14/575 ,  A61K38/00

Abstract: The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.

公开(公告)号：US09902762B2

公开(公告)日：2018-02-27

申请号：US14229415

申请日：2014-03-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  Eric Furfine ,  Irvith M. Carvajal ,  H. Nicholas Marsh ,  Marco Gottardis ,  Joan Carboni ,  Ricardo Attar

IPC: C07K14/705 ,  C07K14/78 ,  C07K14/435 ,  C07K16/46 ,  C07K16/28 ,  A61K38/39 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K47/60 ,  A61K39/395 ,  C07K14/71 ,  C07K14/715 ,  A61K39/00

CPC classification number: C07K14/78 ,  A61K38/39 ,  A61K39/3955 ,  A61K47/60 ,  A61K2039/505 ,  C07K14/71 ,  C07K14/715 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/00 ,  C07K2319/74

Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.

公开(公告)号：US10774130B2

公开(公告)日：2020-09-15

申请号：US15866919

申请日：2018-01-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  Eric Furfine ,  Irvith M. Carvajal ,  H. Nicholas Marsh ,  Marco Gottardis ,  Joan Carboni ,  Ricardo Attar

IPC: C07K14/05 ,  C07K14/78 ,  C07K16/46 ,  C07K16/28 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/39 ,  A61K47/60 ,  A61K39/395 ,  C07K14/71 ,  C07K14/715 ,  A61K39/00

Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.

公开(公告)号：US10221438B2

公开(公告)日：2019-03-05

申请号：US15363724

申请日：2016-11-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael L. Gosselin ,  David Fabrizio ,  Joanna F. Swain ,  Tracy Mitchell ,  Ray Camphausen ,  Sharon T. Cload ,  Eric Furfine ,  Paul E. Morin ,  Ranjan Mukherjee ,  Simeon I. Taylor

IPC: A61K38/00 ,  A61K47/62 ,  A61K47/64 ,  C07K14/50 ,  C07K14/78 ,  C12N15/62 ,  C12P21/00 ,  C07K14/435 ,  C07K14/575

Abstract: The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.

公开(公告)号：US09540424B2

公开(公告)日：2017-01-10

申请号：US14552823

申请日：2014-11-25

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael L. Gosselin ,  David Fabrizio ,  Joanna F. Swain ,  Tracy Mitchell ,  Ray Camphausen ,  Sharon T. Cload ,  Eric Furfine ,  Paul E. Morin ,  Ranjan Mukerjee ,  Simeon I. Taylor

IPC: A61K38/00 ,  C07K14/435 ,  A61K47/48 ,  C07K14/78 ,  C12N15/62 ,  C07K14/50 ,  C07K14/575

CPC classification number: C12P21/005 ,  A61K38/00 ,  A61K47/62 ,  A61K47/643 ,  C07K14/435 ,  C07K14/50 ,  C07K14/575 ,  C07K14/78 ,  C07K2319/70 ,  C12N15/62

Abstract: The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.

Abstract translation: 本发明涉及基于结合血清白蛋白的第十纤连蛋白III型结构域（10Fn3）的抗体样蛋白。 本发明还涉及包含与用于诊断和治疗应用的异源蛋白质连接的血清白蛋白结合10Fn3的融合分子。