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1.发明申请公开(公告)号：US20220031860A1
公开(公告)日：2022-02-03
申请号：US17297830
申请日：2019-12-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Pavel STROP , Chetana RAO-NAIK , Xiaodi DENG , Paul O. SHEPPARD , Sean Matthew WEST , Jason Michael HOGAN , Sayumi YAMAZOE
Abstract: Antibodies are modified by replacing amino acids in the heavy chain CH1, CH2, or CH3 or light chain constant region with selected replacement glutamine-containing sequences to render them amenable to conjugation by the enzyme transglutaminase.
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