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1.发明申请公开(公告)号：US20220031860A1
公开(公告)日：2022-02-03
申请号：US17297830
申请日：2019-12-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Pavel STROP , Chetana RAO-NAIK , Xiaodi DENG , Paul O. SHEPPARD , Sean Matthew WEST , Jason Michael HOGAN , Sayumi YAMAZOE
Abstract: Antibodies are modified by replacing amino acids in the heavy chain CH1, CH2, or CH3 or light chain constant region with selected replacement glutamine-containing sequences to render them amenable to conjugation by the enzyme transglutaminase.
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公开(公告)号：US20190248893A1
公开(公告)日：2019-08-15
申请号：US16316991
申请日：2017-07-13
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Y. HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
IPC: C07K16/28 , A61K47/68 , A61P35/00 , G01N33/574
CPC classification number: C07K16/2803 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/30 , C07K16/3046 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/57492
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20240209083A1
公开(公告)日：2024-06-27
申请号：US18481884
申请日：2023-10-05
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Y. HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
CPC classification number: C07K16/2803 , A61K47/6849 , A61P35/00 , C07K16/2818 , C07K16/2827 , C07K16/2878 , C07K16/30 , C07K16/3046 , G01N33/57492 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20220016260A1
公开(公告)日：2022-01-20
申请号：US17297796
申请日：2019-11-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Pavel STROP , Chetana RAO-NAIK , Xiaodi DENG , Paul O. SHEPPARD , Patrick G. HOLDER , Sayumi YAMAZOE
Abstract: An antibody has a glutamine-containing extension at the C-terminus of a light chain thereof, making it suitable for conjugation via transglutaminase-mediated transamidation.
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公开(公告)号：US20250115664A1
公开(公告)日：2025-04-10
申请号：US18891677
申请日：2024-09-20
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Yu-Cheng HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.
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Patent Agency Ranking
公开(公告)号：US20180016336A1
公开(公告)日：2018-01-18
申请号：US15649380
申请日：2017-07-13
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TROUNG
CPC classification number: C07K16/2803 , A61K2039/505 , A61K2039/507 , C07K16/2827 , C07K16/30 , C07K16/3046 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20240174749A1
公开(公告)日：2024-05-30
申请号：US18476098
申请日：2023-09-27
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Yu-Cheng HUANG , Guodong CHEN , Michelle Renne KUHNE , Hong-An TRUONG , Poliana PATAH , Jeffrey R. JACKSON , Ronald A. FLEMING
IPC: C07K16/28 , A61K39/00 , A61K39/395 , A61P35/00
CPC classification number: C07K16/2803 , A61K39/3955 , A61P35/00 , C07K16/2818 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/21 , C07K2317/52 , C07K2317/565
Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.
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公开(公告)号：US20230382992A1
公开(公告)日：2023-11-30
申请号：US18175420
申请日：2023-02-27
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
IPC: C07K16/28 , C07K16/30 , A61K47/68 , A61P35/00 , G01N33/574
CPC classification number: C07K16/2803 , C07K16/2827 , C07K16/30 , C07K16/3046 , A61K47/6849 , A61P35/00 , C07K16/2818 , C07K16/2878 , G01N33/57492 , A61K2039/507
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20220089720A1
公开(公告)日：2022-03-24
申请号：US16961545
申请日：2019-01-11
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Yu-Cheng HUANG , Guodong CHEN , Michelle KUHNE , Hong-An TRUONG
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.
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公开(公告)号：US20210363242A1
公开(公告)日：2021-11-25
申请号：US16962805
申请日：2019-01-15
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min SCHEBYE , Mark J. SELBY , Michelle Minhua HAN , Christine BEE , Andy X. DENG , Anan CHUNTHARAPAI , Brigitte DEVAUX , Huiming LI , Paul O. SHEPPARD , Alan J. KORMAN , Daniel F. ARDOUREL , Ekaterina DEYANOVA , Richard Yu-Cheng HUANG , Guodong CHEN , Michelle Renne KUHNE , Hong-An TRUONG , Poliana PATAH , Jeffrey R. JACKSON , Ronald A. FLEMING
IPC: C07K16/28 , A61K39/395 , A61P35/00
Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.
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