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公开(公告)号：US20220016260A1
公开(公告)日：2022-01-20
申请号：US17297796
申请日：2019-11-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Pavel STROP , Chetana RAO-NAIK , Xiaodi DENG , Paul O. SHEPPARD , Patrick G. HOLDER , Sayumi YAMAZOE
Abstract: An antibody has a glutamine-containing extension at the C-terminus of a light chain thereof, making it suitable for conjugation via transglutaminase-mediated transamidation.
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公开(公告)号：US20220251206A1
公开(公告)日：2022-08-11
申请号：US17617552
申请日：2020-06-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stanley R. KRYSTEK JR. , Chetana RAO-NAIK , Gregory D. VITE , Paul E. MORIN , Zheng LIN
Abstract: An anti-CTLA4 antibody can be prodrugged by replacement of certain complementarity determining region (CDR) amino acids with a cysteine (Cys), which provides a chemical functionality for attachment of a blocking moiety that can be cleaved at the site of intended action, thus releasing the un-prodrugged antibody.
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公开(公告)号：US20180362619A1
公开(公告)日：2018-12-20
申请号：US16061646
申请日：2016-12-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Paul O. SHEPPARD , Henrik ANDERSEN , Xiang SHAO , Chetana RAO-NAIK , Arvind RAJPAL
Abstract: Variant antibodies having cysteine substitutions at selected positions in the Fc region can be conjugated via the thiol group of the substituted-in cysteine.
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Patent Agency Ranking
公开(公告)号：US20180037921A1
公开(公告)日：2018-02-08
申请号：US15555594
申请日：2016-03-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Chetana RAO-NAIK , Shrikant DESHPANDE
Abstract: An antibody has at a heavy chain thereof a C-terminal extension that includes at least one glutamine that is a substrate for transglutaminase, enabling the transglutaminase-mediated preparation antibody-drug conjugates using such antibody.
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公开(公告)号：US20180282712A1
公开(公告)日：2018-10-04
申请号：US15763962
申请日：2016-09-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Chetana RAO-NAIK
Abstract: A variant transglutaminase having increased specific activity compared to wild-type Streptomyces mobaraensis transglutaminase can be used for conjugating proteins.
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6.发明申请公开(公告)号：US20170326249A1
公开(公告)日：2017-11-16
申请号：US15587963
申请日：2017-05-05
Applicant: Bristol-Myers Squibb Company
Inventor： Chin PAN , Josephine M. CARDARELLI , Haichun HUANG , Sanjeev GANGWAR , Qiang CONG , Karla A. HENNING , Chetana RAO-NAIK , Mohan SRINIVASAN , Vangipuram S. RANGAN , Francis Y. LEE , Ginger C. RAKESTRAW
CPC classification number: A61K47/6829 , A61K9/0019 , A61K47/6803 , A61K47/6849 , A61K47/6853 , C07K5/0205 , C07K16/303 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92
Abstract: An antibody-drug conjugate having a structure represented by formula (I) wherein m is 1, 2, 3, or 4 and Ab is an anti-glypican-3 antibody having heavy and light chain CDRs as disclosed herein.
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7.发明申请公开(公告)号：US20220031860A1
公开(公告)日：2022-02-03
申请号：US17297830
申请日：2019-12-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Pavel STROP , Chetana RAO-NAIK , Xiaodi DENG , Paul O. SHEPPARD , Sean Matthew WEST , Jason Michael HOGAN , Sayumi YAMAZOE
Abstract: Antibodies are modified by replacing amino acids in the heavy chain CH1, CH2, or CH3 or light chain constant region with selected replacement glutamine-containing sequences to render them amenable to conjugation by the enzyme transglutaminase.
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公开(公告)号：US20180265851A1
公开(公告)日：2018-09-20
申请号：US15763677
申请日：2016-09-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Chetana RAO-NAIK , Ganapathy N. SARMA , Akbar NAYEEM
CPC classification number: C12N9/1044 , A61K47/68 , A61K47/6803 , A61K47/6849 , C12P21/00 , C12Y203/02013
Abstract: Transglutaminase variants capable of conjugating an antibody that is not conjugated by wild-type transglutaminase from Streptomyces mobaraensis.
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