公开(公告)号：US11591314B2

公开(公告)日：2023-02-28

申请号：US17101411

申请日：2020-11-23

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Ronald Carrasquillo ,  Peng Geng ,  Eric C. Huang ,  Kishta Katipally ,  Andrew Lee ,  Boguslaw Mudryk ,  Xinhua Qian ,  Thomas M. Razler ,  Jianji Wang ,  Carolyn S. Wei ,  Steven R. Wisniewski ,  Ye Zhu

IPC分类号： C07D403/10

摘要： Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

公开(公告)号：US20210078980A1

公开(公告)日：2021-03-18

申请号：US17101411

申请日：2020-11-23

申请人： Bristol-Myers Squibb Company

发明人： Ronald Carrasquillo ,  Peng Geng ,  Eric C. Huang ,  Kishta Katipally ,  Andrew Lee ,  Boguslaw Mudryk ,  Xinhua Qian ,  Thomas M. Razler ,  Jianji Wang ,  Carolyn S. Wei ,  Steven R. Wisniewski ,  Ye Zhu

IPC分类号： C07D403/10

摘要： Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

公开(公告)号：US20220177482A1

公开(公告)日：2022-06-09

申请号：US17677312

申请日：2022-02-22

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C.D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC分类号： C07D487/04

摘要： The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

公开(公告)号：US20200223852A1

公开(公告)日：2020-07-16

申请号：US16631915

申请日：2018-07-19

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C.D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC分类号： C07D487/04

摘要： The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

公开(公告)号：US11254679B2

公开(公告)日：2022-02-22

申请号：US16631915

申请日：2018-07-19

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C. D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC分类号： C07D487/04

摘要： The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.