公开(公告)号：US20230271946A1

公开(公告)日：2023-08-31

申请号：US18134564

申请日：2023-04-13

申请人： Bristol-Myers Squibb Company

发明人： Ke Chen ,  Joerg Deerberg ,  Dong Lin ,  Michael Dummeldinger ,  Bahar Inankur ,  Sergei Kolotuchin ,  Jun Li ,  Amanda J. Rogers ,  Victor W. Rosso ,  Eric M. Simmons ,  Maxime C.D. Soumeillant ,  Daniel S. Treitler ,  Jianji Wang ,  Bin Zheng ,  Michael J. Smith ,  Neil A. Strotman ,  Steven Tymonko ,  Tamas Benkovics

IPC分类号： C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08

CPC分类号： C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08 ,  C07B2200/13

摘要： The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-5N-(methyl-d3)pyridazine-3-carboxamide of the formula:




Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

公开(公告)号：US11591314B2

公开(公告)日：2023-02-28

申请号：US17101411

申请日：2020-11-23

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Ronald Carrasquillo ,  Peng Geng ,  Eric C. Huang ,  Kishta Katipally ,  Andrew Lee ,  Boguslaw Mudryk ,  Xinhua Qian ,  Thomas M. Razler ,  Jianji Wang ,  Carolyn S. Wei ,  Steven R. Wisniewski ,  Ye Zhu

IPC分类号： C07D403/10

摘要： Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

公开(公告)号：US20210107897A1

公开(公告)日：2021-04-15

申请号：US17131718

申请日：2020-12-22

申请人： Bristol-Myers Squibb Company

发明人： Ke Chen ,  Joerg Deerberg ,  Dong Lin ,  Michael Dummeldinger ,  Bahar Inankur ,  Sergei Kolotuchin ,  Jun Li ,  Amanda J. Rogers ,  Victor W. Rosso ,  Eric M. Simmons ,  Maxime C.D. Soumeillant ,  Daniel S. Treitler ,  Jianji Wang ,  Bin Zheng ,  Michael J. Smith ,  Neil A. Strotman ,  Steven Tymonko ,  Tamas Benkovics

IPC分类号： C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08

摘要： The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

公开(公告)号：US20210078980A1

公开(公告)日：2021-03-18

申请号：US17101411

申请日：2020-11-23

申请人： Bristol-Myers Squibb Company

发明人： Ronald Carrasquillo ,  Peng Geng ,  Eric C. Huang ,  Kishta Katipally ,  Andrew Lee ,  Boguslaw Mudryk ,  Xinhua Qian ,  Thomas M. Razler ,  Jianji Wang ,  Carolyn S. Wei ,  Steven R. Wisniewski ,  Ye Zhu

IPC分类号： C07D403/10

摘要： Disclosed is a process for preparing Compound 8: comprising the step of reacting Compound of 7: wherein R is C1-8 alkyl or benzyl in the presence of a base. Also disclosed are intermediates and processes for preparing the intermediates.

公开(公告)号：US10899745B2

公开(公告)日：2021-01-26

申请号：US16498442

申请日：2018-03-29

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Ke Chen ,  Joerg Deerberg ,  Dong Lin ,  Michael Dummeldinger ,  Bahar Inankur ,  Sergei Kolotuchin ,  Jun Li ,  Amanda J. Rogers ,  Victor W. Rosso ,  Eric M. Simmons ,  Daniel S. Treitler ,  Jianji Wang ,  Michael J. Smith ,  Tamas Benkovics

IPC分类号： C07D403/12 ,  C07C211/09 ,  C07D237/24 ,  C07D249/08

摘要： The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.