公开(公告)号：US10669261B2

公开(公告)日：2020-06-02

申请号：US16061365

申请日：2016-12-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael C. Myers ,  R. Michael Lawrence ,  Donna M. Bilder ,  Wei Meng ,  Zulan Pi ,  Robert Paul Brigance ,  Heather Finlay

IPC: A61K31/506 ,  A61K31/513 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P9/00

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.

公开(公告)号：US20140235673A1

公开(公告)日：2014-08-21

申请号：US14347662

申请日：2012-09-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  John Llyod ,  Jennifer X. Qiao ,  Tammy C. Wang ,  George O. Tora

IPC: C07D213/81 ,  C07D413/04 ,  C07D401/12 ,  C07D213/89 ,  C07D401/04 ,  C07D409/04

CPC classification number: C07D213/81 ,  C07D213/34 ,  C07D213/89 ,  C07D401/04 ,  C07D401/12 ,  C07D409/04 ,  C07D413/04

Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US20170275272A1

公开(公告)日：2017-09-28

申请号：US15468230

申请日：2017-03-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  Donna M. Bilder ,  Robert Paul Brigance ,  Heather Finlay ,  Wen Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Wei Meng ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Xiaojun Zhang

IPC: C07D403/06 ,  C07D471/04 ,  C07D417/14 ,  C07D401/14

CPC classification number: C07D403/06 ,  A61K31/505 ,  C07D239/54 ,  C07D239/545 ,  C07D239/557 ,  C07D401/06 ,  C07D401/14 ,  C07D403/02 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US09139578B2

公开(公告)日：2015-09-22

申请号：US14413370

申请日：2013-07-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  Jennifer X. Qiao ,  George O. Tora ,  Tammy C. Wang

IPC: C07D417/14 ,  C07D417/06

CPC classification number: C07D417/14 ,  C07D417/06

Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US20150259286A1

公开(公告)日：2015-09-17

申请号：US14418023

申请日：2013-07-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alexandre L'Heureux ,  Sheldon Hiebert ,  Carol Hu ,  Patrick Y.S. Lam ,  John Lloyd ,  Zulan Pi ,  Jennifer X. Qiao ,  Carl Thibeault ,  George O. Tora ,  Wu Yang ,  Yufeng Wang ,  Tammy C. Wang ,  Michael S. Bowsher ,  Ruel Rejean

IPC: C07D209/26 ,  C07D401/12 ,  C07D403/12 ,  C07D513/04 ,  C07D413/04 ,  C07D401/04 ,  C07D403/04 ,  C07D498/04 ,  C07D417/14 ,  C07D413/14 ,  C07D409/04 ,  C07D417/12 ,  C07D417/04

CPC classification number: C07D209/26 ,  C07D209/14 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention provides compounds of Formula (I): Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are antagonists of P2Y1 receptor which may be used medicaments.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义的式（I）和包含任何这些新化合物的组合物。 这些化合物是可以使用药物的P2Y1受体的拮抗剂。

公开(公告)号：US20150158856A1

公开(公告)日：2015-06-11

申请号：US14413370

申请日：2013-07-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  Jennifer X. Qiao ,  George O. Tora ,  Tammy C. Wang

IPC: C07D417/14 ,  C07D417/06

CPC classification number: C07D417/14 ,  C07D417/06

Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US20140011799A1

公开(公告)日：2014-01-09

申请号：US13936311

申请日：2013-07-08

Applicant: Bristol-Myers Squibb Company

Inventor： James A. Johnson ,  Ji Jiang ,  Soong-Hoon Kim ,  Zulan Pi ,  Jennifer X. Qiao ,  George O. Tora ,  Tammy C. Wang ,  Heather Finlay

IPC: C07D417/06 ,  C07D417/14

CPC classification number: C07D417/06 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US12281108B2

公开(公告)日：2025-04-22

申请号：US17295092

申请日：2019-11-25

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Nicholas R. Wurtz ,  James A. Johnson ,  Zulan Pi ,  Andrew Quoc Viet

IPC: C07D413/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D498/04 ,  A61K31/423 ,  A61K31/4245 ,  A61K31/433 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00

Abstract: The disclosure relates to compounds of formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, and related diseases.

公开(公告)号：US10590113B2

公开(公告)日：2020-03-17

申请号：US16122975

申请日：2018-09-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zulan Pi ,  Donna M. Bilder ,  Robert Paul Brigance ,  Heather Finlay ,  Wen Jiang ,  James A. Johnson ,  R. Michael Lawrence ,  Wei Meng ,  Michael C. Myers ,  Monique Phillips ,  George O. Tora ,  Xiaojun Zhang

IPC: A61K31/505 ,  C07D403/06 ,  C07D401/06 ,  C07D403/14 ,  C07D239/557 ,  C07D239/54 ,  C07D239/545 ,  C07D401/14 ,  C07D403/02 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

公开(公告)号：US09120794B2

公开(公告)日：2015-09-01

申请号：US14575171

申请日：2014-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Lynn Abell ,  Leonard Adam ,  Cullen L. Cavallaro ,  Heather Finlay ,  Todd J. Friends ,  Jon J. Hangeland ,  Ji Jang ,  R. Michael Lawrence ,  John Lloyd ,  Zulan Pi ,  George O. Tora ,  Jennifer X. Qiao ,  Carol Hui Hu ,  Tammy C. Wang

IPC: C07D471/04 ,  C07D403/12 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D417/04 ,  C07D417/06 ,  C07D207/28 ,  C07D207/38 ,  C07D417/12 ,  C07D487/04 ,  C07D413/06

CPC classification number: C07D471/04 ,  C07D207/28 ,  C07D207/38 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I) or Formula (III): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供式（I）或式（III）的化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。