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1.发明授权公开(公告)号：US11963969B2
公开(公告)日：2024-04-23
申请号：US17932781
申请日：2022-09-16
发明人： Chia-Yu Chang , Shinn-Zong Lin , Hsiao-Chien Ting , Hui-I Yang , Horng-Jyh Harn , Hong-Lin Su , Ching-Ann Liu , Yu-Shuan Chen , Tzyy-Wen Chiou , Tsung-Jung Ho
IPC分类号： A61K31/7034 , A61K9/00 , A61K31/428 , A61P25/28
CPC分类号： A61K31/7034 , A61K9/0019 , A61K31/428 , A61P25/28
摘要： Provided is a pharmaceutical composition including gastrodin and a use thereof for the prevention or the treatment of amyotrophic lateral sclerosis. The pharmaceutical composition is effective in reducing neuronal axon degeneration and neurofibromin accumulation, improving symptoms of amyotrophic lateral sclerosis and extending life of patients of amyotrophic lateral sclerosis.
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公开(公告)号：US20220096431A1
公开(公告)日：2022-03-31
申请号：US17491064
申请日：2021-09-30
发明人： Shinn-Zong Lin , Horng-Jyh Harn , Tzyy-Wen Chiou , Wei Wuli
IPC分类号： A61K31/365 , A61K31/7088 , A61K31/375 , A61P25/28 , C12Q1/6883
摘要： Provided is a pharmaceutical composition and method for preventing, treating and diagnosing a neurodegenerative disease in a subject in need thereof. The method includes obtaining a biological sample from the subject and determining an expression level of a miRNA, and stimulating expression of the miRNA. Also provided is a kit for diagnosing a neurodegenerative disease in a subject in need thereof.
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公开(公告)号：US20230149678A1
公开(公告)日：2023-05-18
申请号：US17454750
申请日：2021-11-12
发明人： Yu-Shuan Chen , Hsieh-Chih Tsai , Chang-Yi Lee , Haile Fentahun Darge , Shinn-Zong Lin , Tzyy-Wen Chiou , Chia-Yu Chang
IPC分类号： A61M37/00 , C08F220/38 , C08F220/56
CPC分类号： A61M37/0015 , C08F220/387 , C08F220/56 , A61M2037/0023 , A61M2037/0046 , A61M2037/0053 , A61M2207/10 , A61M2205/02
摘要： Provided is a device for transdermal delivery of drugs. The device includes a separable substrate and is loaded with dual drugs based on an interpenetrating polymer network hydrogel. Also provided are methods of making and using the transdermal delivery device.
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