公开(公告)号：US20240228953A1

公开(公告)日：2024-07-11

申请号：US18359053

申请日：2023-07-26

申请人： BUDDHIST TZU CHI MEDICAL FOUNDATION

发明人： WU LI Wei ,  Shinn-Zong LIN ,  Tzyy-Wen CHIOU ,  Horng-Jyh HARN ,  Peng-Yeong WOON

IPC分类号： C12N5/079 ,  C12N5/00

CPC分类号： C12N5/0618 ,  C12N5/0018 ,  C12N2500/38 ,  C12N2501/15 ,  C12N2501/2306 ,  C12N2501/2308 ,  C12N2501/998 ,  C12N2501/999

摘要： A method for promoting proliferation and enhancing expression of pluripotency factors of stem cells and a method for promoting proliferation of cells differentiated from the stem cells are provided in the present disclosure. The methods comprise culturing the stem cells in a medium comprising thrombospondin 1 (TSP1) and left-right determination factor 2 (LEFTY2). The present disclosure also provides a composition comprising a derivative of the stem cells produced by the methods of the present disclosure and a pharmaceutically or cosmetically acceptable carrier.