公开(公告)号：US20240228953A1

公开(公告)日：2024-07-11

申请号：US18359053

申请日：2023-07-26

申请人： BUDDHIST TZU CHI MEDICAL FOUNDATION

发明人： WU LI Wei ,  Shinn-Zong LIN ,  Tzyy-Wen CHIOU ,  Horng-Jyh HARN ,  Peng-Yeong WOON

IPC分类号： C12N5/079 ,  C12N5/00

CPC分类号： C12N5/0618 ,  C12N5/0018 ,  C12N2500/38 ,  C12N2501/15 ,  C12N2501/2306 ,  C12N2501/2308 ,  C12N2501/998 ,  C12N2501/999

摘要： A method for promoting proliferation and enhancing expression of pluripotency factors of stem cells and a method for promoting proliferation of cells differentiated from the stem cells are provided in the present disclosure. The methods comprise culturing the stem cells in a medium comprising thrombospondin 1 (TSP1) and left-right determination factor 2 (LEFTY2). The present disclosure also provides a composition comprising a derivative of the stem cells produced by the methods of the present disclosure and a pharmaceutically or cosmetically acceptable carrier.

公开(公告)号：US20230263813A1

公开(公告)日：2023-08-24

申请号：US17932781

申请日：2022-09-16

申请人： BUDDHIST TZU CHI MEDICAL FOUNDATION

发明人： Chia-Yu CHANG ,  Shinn-Zong LIN ,  Hsiao-Chien TING ,  Hui-I YANG ,  Horng-Jyh HARN ,  Hong-Lin SU ,  Ching-Ann LIU ,  Yu-Shuan CHEN ,  Tzyy-Wen CHIOU ,  Tsung-Jung HO

IPC分类号： A61K31/7034 ,  A61K9/00 ,  A61K31/428 ,  A61P25/28

CPC分类号： A61K31/7034 ,  A61K9/0019 ,  A61K31/428 ,  A61P25/28

摘要： Provided is a pharmaceutical composition including gastrodin and a use thereof for the prevention or the treatment of amyotrophic lateral sclerosis. The pharmaceutical composition is effective in reducing neuronal axon degeneration and neurofibromin accumulation, improving symptoms of amyotrophic lateral sclerosis and extending life of patients of amyotrophic lateral sclerosis.