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公开(公告)号：US20140051133A1
公开(公告)日：2014-02-20
申请号：US13891963
申请日：2013-05-10
发明人： Sridhar Govindarajan , Yougen Li , Der-Ing Liao , Daniel P. O'Keefe , Jeremy Stephen Minshull , Steven Cary Rothman , Alexander Vincent Tobias
IPC分类号： C12N9/04
CPC分类号： C12N9/0006 , C12P7/16 , C12P7/42 , C12P7/44 , C12P13/02 , C12P13/06 , C12P13/08 , C12Y101/01086 , Y02E50/10 , Y02P20/52
摘要： Provided herein are polypeptides having ketol-aid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways.
摘要翻译： 本文提供具有酮促辅助还原异构酶活性的多肽以及包含这种多肽的微生物宿主细胞。 本文提供的多肽可用于生物合成途径，包括但不限于异丁醇生物合成途径。
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公开(公告)号：US20160032255A1
公开(公告)日：2016-02-04
申请号：US14853108
申请日：2015-09-14
发明人： Sridhar Govindarajan , Yougen Li , Der-Ing Liao , Daniel P. O'Keefe , Jeremy Stephen Minshull , Steven Cary Rothman , Alexander Vincent Tobias
CPC分类号： C12N9/0006 , C12P7/16 , C12P7/42 , C12P7/44 , C12P13/02 , C12P13/06 , C12P13/08 , C12Y101/01086 , Y02E50/10 , Y02P20/52
摘要： Provided herein are polypeptides having ketol-acid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways.
摘要翻译： 本文提供具有酮酸酸还原异构酶活性的多肽以及包含这些多肽的微生物宿主细胞。 本文提供的多肽可用于生物合成途径，包括但不限于异丁醇生物合成途径。
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公开(公告)号：US09944954B2
公开(公告)日：2018-04-17
申请号：US15228770
申请日：2016-08-04
发明人： Ritu Bhalla , Gopal K. Chotani , Michael Dauner , Mark J. Nelson , Daniel P. O'Keefe , Caroline M. Peres , Jahnavi Chandra Prasad , Jean-Francois Tomb
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N15/52 , C12Y101/01008 , C12Y101/01094 , C12Y101/05003 , C12Y102/01012 , Y02E50/10 , Y02P20/52
摘要： Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased KM for NADH and GPD enzymes with substantially the same affinity for NADH and NADPH and/or are feedback inhibited by glycerol-3-phosphate. Also provided herein are recombinant microorganisms comprising a heterologous gene encoding GPD and a deletion or disruption in an endogenous gene encoding GPD. Also provided are recombinant microorganisms comprising a heterologous gene encoding GPD and a butanol biosynthetic pathway. Further provided are methods of producing butanol comprising providing the recombinant microorganisms described herein and contacting the recombinant microorganism with at least one fermentable carbon substrate under conditions wherein butanol is produced.
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公开(公告)号：US09388392B2
公开(公告)日：2016-07-12
申请号：US14853108
申请日：2015-09-14
发明人： Sridhar Govindarajan , Yougen Li , Der-Ing Liao , Daniel P. O'Keefe , Jeremy Stephen Minshull , Steven Cary Rothman , Alexander Vincent Tobias
CPC分类号： C12N9/0006 , C12P7/16 , C12P7/42 , C12P7/44 , C12P13/02 , C12P13/06 , C12P13/08 , C12Y101/01086 , Y02E50/10 , Y02P20/52
摘要： Provided herein are polypeptides having ketol-acid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways.
摘要翻译： 本文提供具有酮酸酸还原异构酶活性的多肽以及包含这些多肽的微生物宿主细胞。 本文提供的多肽可用于生物合成途径，包括但不限于异丁醇生物合成途径。
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5.发明授权Alcohol dehydrogenases (ADH) useful for fermentive production of lower alkyl alcohols 有权用于发酵生产低级烷基醇的醇脱氢酶（ADH）公开(公告)号：US09410166B2
公开(公告)日：2016-08-09
申请号：US14282722
申请日：2014-05-20
CPC分类号： C12P7/16 , C12N9/0004 , C12N15/81 , Y02E50/10 , Y02P20/52
摘要： The invention relates to suitable candidate alcohol dehydrogenase (ADH) enzymes for production of lower alkyl alcohols including isobutanol. The invention also relates to recombinant host cells that comprise such ADH enzymes and methods for producing lower alkyl alcohols in the same.
摘要翻译： 本发明涉及用于生产低级烷基醇（包括异丁醇）的合适的候选醇脱氢酶（ADH）酶。 本发明还涉及包含这种ADH酶的重组宿主细胞及其制备其中的低级烷基醇的方法。
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公开(公告)号：US09169467B2
公开(公告)日：2015-10-27
申请号：US13891963
申请日：2013-05-10
发明人： Sridhar Govindarajan , Yougen Li , Der-Ing Liao , Daniel P. O'Keefe , Jeremy Stephen Minshull , Steven Cary Rothman , Alexander Vincent Tobias
CPC分类号： C12N9/0006 , C12P7/16 , C12P7/42 , C12P7/44 , C12P13/02 , C12P13/06 , C12P13/08 , C12Y101/01086 , Y02E50/10 , Y02P20/52
摘要： Provided herein are polypeptides having ketol-aid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways.
摘要翻译： 本文提供具有酮促辅助还原异构酶活性的多肽以及包含这种多肽的微生物宿主细胞。 本文提供的多肽可用于生物合成途径，包括但不限于异丁醇生物合成途径。
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